RGD Reference Report - Polymorphisms in GC and NADSYN1 Genes are associated with vitamin D status and metabolic profile in Non-diabetic adults. - Rat Genome Database

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Polymorphisms in GC and NADSYN1 Genes are associated with vitamin D status and metabolic profile in Non-diabetic adults.

Authors: Foucan, Lydia  Vélayoudom-Céphise, Fritz-Line  Larifla, Laurent  Armand, Christophe  Deloumeaux, Jacqueline  Fagour, Cedric  Plumasseau, Jean  Portlis, Marie-Line  Liu, Longjian  Bonnet, Fabrice  Ducros, Jacques 
Citation: Foucan L, etal., BMC Endocr Disord. 2013 Sep 29;13:36. doi: 10.1186/1472-6823-13-36.
RGD ID: 13703112
Pubmed: PMID:24073860   (View Abstract at PubMed)
PMCID: PMC3849583   (View Article at PubMed Central)
DOI: DOI:10.1186/1472-6823-13-36   (Journal Full-text)


BACKGROUND: Our aim was to assess the associations between vitamin D (vitD) status, metabolic profile and polymorphisms in genes involved in the transport (Group-Component: GC) and the hydroxylation (NAD synthetase 1: NADSYN1) of 25 hydroxyvitamin D (25(OH)D) in non-diabetic individuals.
METHODS: We conducted a cross-sectional study with 323 individuals recruited from the Health Center of Guadeloupe, France. The rs2282679 T¿>¿G and rs2298849 T¿>¿C in GC and rs12785878 G¿>¿T in NADSYN1 were genotyped.
RESULTS: Mean age was 46(range 18-86) years. 57% of participants had vitD insufficiency, 8% had vitD deficiency, 61% were overweight and 58% had dyslipidemia. A higher frequency of overweight was noted in women carrying rs2298849T allele v CC carriers (71% v 50%; P¿=¿0.035). The rs2282679G allele was associated with increased risks of vitD deficiency and vitD insufficiency (OR =3.53, P¿=¿0.008, OR¿=¿2.34, P¿=¿0.02 respectively). The rs2298849 TT genotype was associated with vitD deficiency and overweight (OR =3.4, P¿=¿0.004 and OR¿=¿1.76, P¿=¿0.04 respectively) and the rs12785878 GG genotype with vitD insufficiency and dyslipidemia (OR¿=¿1.80, P¿=¿0.01 and OR¿=¿1.72, P¿=¿0.03 respectively). Based on the number of risk alleles for rs2282679 and rs12785878 combined, a genotype score of 3 (vs. 0-1) was associated with a 5.5 ng/mL average reduction in serum 25(OH)D levels (P¿=¿0.001).
CONCLUSIONS: The GC and NADSYN1 genes are associated with the vitamin D status and might contribute to dyslipidemia and overweight independently of 25(OH)D levels.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NADSYN1HumanDyslipidemias susceptibilityIAGP DNA:SNP: :rs12785878 G>T(human)RGD 
Nadsyn1RatDyslipidemias susceptibilityISORGD:1602697DNA:SNP: :rs12785878 G>T(human)RGD 
Nadsyn1MouseDyslipidemias susceptibilityISORGD:1602697DNA:SNP: :rs12785878 G>T(human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NADSYN1HumanDecreased circulating vitamin D concentration  IAGP DNA:SNP: :rs12785878 G>T(human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Nadsyn1  (NAD synthetase 1)

Genes (Mus musculus)
Nadsyn1  (NAD synthetase 1)

Genes (Homo sapiens)
NADSYN1  (NAD synthetase 1)


Additional Information