RGD Reference Report - MicroRNA-518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB. - Rat Genome Database

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MicroRNA-518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB.

Authors: Xu, Xiaolong  Zhang, Fenglin  Chen, Xianzhen  Ying, Qi 
Citation: Xu X, etal., Mol Med Rep. 2017 Oct;16(4):5326-5332. doi: 10.3892/mmr.2017.7298. Epub 2017 Aug 21.
RGD ID: 13703042
Pubmed: PMID:28849154   (View Abstract at PubMed)
PMCID: PMC5647064   (View Article at PubMed Central)
DOI: DOI:10.3892/mmr.2017.7298   (Journal Full-text)

Glioblastoma (GBM) is the most common and aggressive type of primary human brain tumor in China. Dysregulated microRNA (miRNA/miR) expression has been hypothesized to serve a role in the tumorigenesis and progression of human GBM. To explore the potential mechanisms affecting GBM tumorigenesis, the function of miR-518b in regulating GBM cell proliferation and angiogenesis was examined in vitro by CCK-8 and tube formation assay and in vivo by xenograft assay. The present study demonstrated that the expression of miR-518b was downregulated in GBM tissues and in GBM cell lines (U87 and U251). In addition, the expression levels of miR-518b were highly associated with tumor size, World Health Organization grade and prognosis. Furthermore, overexpression of miR-518b suppressed GBM cell proliferation and angiogenesis, and induced GBM cell apoptosis in vitro and in vivo. Overexpression of miR-518b also inhibited the expression of platelet-derived growth factor receptor ß (PDGFRB), and the present study confirmed that the 3' untranslated region (3'UTR) of PDGFRB was a direct target of miR-518b. In conclusion, to the best of our knowledge, the present study is the first to present evidence suggesting that miR-518b may serve as a potential marker and target in GBM treatment.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
glioblastoma disease_progressionIEP 13703042 RGD 

Objects Annotated

Genes (Homo sapiens)
MIR518B  (microRNA 518b)


Additional Information