RGD Reference Report - Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo.

Authors: Huang, Ying-Juan  Jin, Ming-Hua  Pi, Rong-Biao  Zhang, Jun-Jie  Ouyang, Ying  Chao, Xiao-Juan  Chen, Mei-Hui  Liu, Pei-Qing  Yu, Jian-Chen  Ramassamy, Charles  Dou, Juan  Chen, Xiao-Hong  Jiang, Yi-Ming  Qin, Jian 
Citation: Huang YJ, etal., Toxicol Lett. 2013 Mar 13;217(3):184-91. doi: 10.1016/j.toxlet.2012.12.023. Epub 2013 Jan 4.
RGD ID: 13703032
Pubmed: PMID:23296102   (View Abstract at PubMed)
DOI: DOI:10.1016/j.toxlet.2012.12.023   (Journal Full-text)

The pathologic mechanisms of Alzheimer's disease (AD) have not been fully uncovered. Acrolein, a ubiquitous dietary pollutant and by-product of oxidative stress, can induce cytotoxicity in neurons, which might play an important role in the etiology of AD. Here, we examined the effects of Acrolein on the AD pathologies in vitro and in vivo. We found Acrolein induced HT22 cells death in concentration- and time-dependent manners. Interestingly, Acrolein increased proteins' levels of amyloid precursor protein (APP), ß-secretase (BACE-1) and the amyloid ß-peptide transporter receptor for advanced glycation end products, and decreased A-disintegrin and metalloprotease (ADAM) 10 levels. In vivo, chronic oral exposure to Acrolein (2.5 mg/kg/day by intragastric gavage for 8 weeks) induced mild cognitive declination and pyknosis/atrophy of hippocampal neurons. The activity of superoxide dismutase was down-regulated while the level of malondialdehyde was up-regulated in rat brain. Moreover, Acrolein resulted in activation of astrocytes, up-regulation of BACE-1 in cortex and down-regulation of ADAM-10 in hippocampus and cortex. Taken together, our findings suggest that exposure to Acrolein induces AD-like pathology in vitro and in vivo. Scavenging Acrolein might be beneficial for the therapy of AD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  ISOAdam10 (Rattus norvegicus)13703032; 13703032protein:decreased expression:cerebral cortex and hippocampusRGD 
Alzheimer's disease  IEP 13703032protein:decreased expression:cerebral cortex and hippocampusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adam10  (ADAM metallopeptidase domain 10)

Genes (Mus musculus)
Adam10  (a disintegrin and metallopeptidase domain 10)

Genes (Homo sapiens)
ADAM10  (ADAM metallopeptidase domain 10)


Additional Information