RGD Reference Report - Glutamate-induced delta-catenin redistribution and dissociation from postsynaptic receptor complexes. - Rat Genome Database

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Glutamate-induced delta-catenin redistribution and dissociation from postsynaptic receptor complexes.

Authors: Jones, S B  Lanford, G W  Chen, Y-H  Morabito, M  Kim, K  Lu, Q 
Citation: Jones SB, etal., Neuroscience. 2002;115(4):1009-21.
RGD ID: 13702427
Pubmed: PMID:12453475   (View Abstract at PubMed)

Delta-catenin (or neural plakophilin-related arm-repeat protein/neurojungin) is primarily a brain specific member of the p120(ctn) subfamily of armadillo/beta-catenin proteins that play important roles in neuronal development. Our previous studies have shown that the ectopic expression of delta-catenin induces the formation of dendrite-like extensions and that the overexpression of delta-catenin promotes dendritic branching and increases spine density. Here we demonstrate that delta-catenin displays a dendritic distribution pattern in the adult mouse brain and is co-enriched with postsynaptic density-95 (PSD-95) in the detergent insoluble postsynaptic scaffolds. Delta-catenin forms stable complexes with excitatory neurotransmitter receptors including ionotropic N-methyl-D-aspartic acid receptor 2A (NR2A), metabotropic glutamate receptor 1alpha (mGluR1alpha), as well as PSD-95 in vivo. In cultured primary embryonic neurons, delta-catenin clusters co-distribute with filamentous actin and resist detergent extraction. In dissociated hippocampal neurons overexpressing delta-catenin, glutamate stimulation leads to a rapid redistribution of delta-catenin that can be attenuated by 6-cyano-7-nitroquinoxaline-2,3-dione and dizocilpine, selective inhibitors of ionotropic glutamate receptors. Upon glutamate receptor activation, delta-catenin becomes down-regulated and its association with NR2A and mGluR1alpha in cultured neurons is diminished. These findings support a possible functional connection between delta-catenin and the glutamatergic excitatory synaptic signaling pathway during neuronal development.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
postsynaptic density is_active_inIDA 13702427PMID:12453475SynGO 
postsynaptic density is_active_inIEP 13702427PMID:12453475SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Ctnnd2  (catenin delta 2)


Additional Information