RGD Reference Report - SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses. - Rat Genome Database

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SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.

Authors: Ko, Jaewon  Kim, Seho  Chung, Hye Sun  Kim, Karam  Han, Kihoon  Kim, Hyun  Jun, Heejung  Kaang, Bong-Kiun  Kim, Eunjoon 
Citation: Ko J, etal., Neuron. 2006 Apr 20;50(2):233-45. doi: 10.1016/j.neuron.2006.04.005.
RGD ID: 13702351
Pubmed: (View Article at PubMed) PMID:16630835
DOI: Full-text: DOI:10.1016/j.neuron.2006.04.005

Synaptic cell adhesion molecules (CAMs) are known to play key roles in various aspects of synaptic structures and functions, including early differentiation, maintenance, and plasticity. We herein report the identification of a family of cell adhesion-like molecules termed SALM that interacts with the abundant postsynaptic density (PSD) protein PSD-95. SALM2, a SALM isoform, distributes to excitatory, but not inhibitory, synaptic sites. Overexpression of SALM2 increases the number of excitatory synapses and dendritic spines. Mislocalized expression of SALM2 disrupts excitatory synapses and dendritic spines. Bead-induced direct aggregation of SALM2 results in coclustering of PSD-95 and other postsynaptic proteins, including GKAP and AMPA receptors. Knockdown of SALM2 by RNA interference reduces the number of excitatory synapses and dendritic spines and the frequency, but not amplitude, of miniature excitatory postsynaptic currents. These results suggest that SALM2 is an important regulator of the differentiation of excitatory synapses.

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Genes (Rattus norvegicus)
Lrfn1  (leucine rich repeat and fibronectin type III domain containing 1)


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