RGD Reference Report - The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development. - Rat Genome Database

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The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development.

Authors: Woo, Jooyeon  Kwon, Seok-Kyu  Nam, Jungyong  Choi, Seungwon  Takahashi, Hideto  Krueger, Dilja  Park, Joohyun  Lee, Yeunkum  Bae, Jin Young  Lee, Dongmin  Ko, Jaewon  Kim, Hyun  Kim, Myoung-Hwan  Bae, Yong Chul  Chang, Sunghoe  Craig, Ann Marie  Kim, Eunjoon 
Citation: Woo J, etal., J Cell Biol. 2013 Jun 10;201(6):929-44. doi: 10.1083/jcb.201209132.
RGD ID: 13702234
Pubmed: (View Article at PubMed) PMID:23751499
DOI: Full-text: DOI:10.1083/jcb.201209132

Synaptic adhesion molecules regulate diverse aspects of synapse formation and maintenance. Many known synaptic adhesion molecules localize at excitatory synapses, whereas relatively little is known about inhibitory synaptic adhesion molecules. Here we report that IgSF9b is a novel, brain-specific, homophilic adhesion molecule that is strongly expressed in GABAergic interneurons. IgSF9b was preferentially localized at inhibitory synapses in cultured rat hippocampal and cortical interneurons and was required for the development of inhibitory synapses onto interneurons. IgSF9b formed a subsynaptic domain distinct from the GABAA receptor- and gephyrin-containing domain, as indicated by super-resolution imaging. IgSF9b was linked to neuroligin 2, an inhibitory synaptic adhesion molecule coupled to gephyrin, via the multi-PDZ protein S-SCAM. IgSF9b and neuroligin 2 could reciprocally cluster each other. These results suggest a novel mode of inhibitory synaptic organization in which two subsynaptic domains, one containing IgSF9b for synaptic adhesion and the other containing gephyrin and GABAA receptors for synaptic transmission, are interconnected through S-SCAM and neuroligin 2.


Gene Ontology Annotations    

Biological Process

Cellular Component

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Igsf9b  (immunoglobulin superfamily, member 9B)
Magi2  (membrane associated guanylate kinase, WW and PDZ domain containing 2)

Additional Information