RGD Reference Report - The expression of vesicular glutamate transporters defines two classes of excitatory synapse. - Rat Genome Database

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The expression of vesicular glutamate transporters defines two classes of excitatory synapse.

Authors: Fremeau, R T  Troyer, M D  Pahner, I  Nygaard, G O  Tran, C H  Reimer, R J  Bellocchio, E E  Fortin, D  Storm-Mathisen, J  Edwards, R H 
Citation: Fremeau RT, etal., Neuron. 2001 Aug 2;31(2):247-60.
RGD ID: 13702232
Pubmed: PMID:11502256   (View Abstract at PubMed)

The quantal release of glutamate depends on its transport into synaptic vesicles. Recent work has shown that a protein previously implicated in the uptake of inorganic phosphate across the plasma membrane catalyzes glutamate uptake by synaptic vesicles. However, only a subset of glutamate neurons expresses this vesicular glutamate transporter (VGLUT1). We now report that excitatory neurons lacking VGLUT1 express a closely related protein that has also been implicated in phosphate transport. Like VGLUT1, this protein localizes to synaptic vesicles and functions as a vesicular glutamate transporter (VGLUT2). The complementary expression of VGLUT1 and 2 defines two distinct classes of excitatory synapse.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc17a6RatL-glutamate transmembrane transport involved_inIDA PMID:11502256UniProt 
Slc17a6Ratneurotransmitter loading into synaptic vesicle involved_inIDA PMID:11502256SynGO 
Slc17a6Ratneurotransmitter loading into synaptic vesicle involved_inIMP PMID:11502256SynGO 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc17a6Ratsynaptic vesicle located_inIDA PMID:11502256UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc17a6RatL-glutamate uniporter activity enablesIDA PMID:11502256UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Slc17a6  (solute carrier family 17 member 6)


Additional Information