RGD Reference Report - Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus. - Rat Genome Database

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Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus.

Authors: Ribeiro, Luís F  Catarino, Tatiana  Santos, Sandra D  Benoist, Marion  van Leeuwen, J Fiona  Esteban, José A  Carvalho, Ana Luísa 
Citation: Ribeiro LF, etal., Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E149-58. doi: 10.1073/pnas.1313798111. Epub 2013 Dec 23.
RGD ID: 13702206
Pubmed: (View Article at PubMed) PMID:24367106
DOI: Full-text: DOI:10.1073/pnas.1313798111

Ghrelin is a peptide mainly produced by the stomach and released into circulation, affecting energy balance and growth hormone release. These effects are guided largely by the expression of the ghrelin receptor growth hormone secretagogue type 1a (GHS-R1a) in the hypothalamus and pituitary. However, GHS-R1a is expressed in other brain regions, including the hippocampus, where its activation enhances memory retention. Herein we explore the molecular mechanism underlying the action of ghrelin on hippocampal-dependent memory. Our data show that GHS-R1a is localized in the vicinity of hippocampal excitatory synapses, and that its activation increases delivery of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic-type receptors (AMPARs) to synapses, producing functional modifications at excitatory synapses. Moreover, GHS-R1a activation enhances two different paradigms of long-term potentiation in the hippocampus, activates the phosphatidylinositol 3-kinase, and increases GluA1 AMPAR subunit and stargazin phosphorylation. We propose that GHS-R1a activation in the hippocampus enhances excitatory synaptic transmission and synaptic plasticity by regulating AMPAR trafficking. Our study provides insights into mechanisms that may mediate the cognition-enhancing effect of ghrelin, and suggests a possible link between the regulation of energy metabolism and learning.

Annotation

Gene Ontology Annotations    

Biological Process

Cellular Component

Objects Annotated

Genes (Rattus norvegicus)
Ghsr  (growth hormone secretagogue receptor)


Additional Information