RGD Reference Report - Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells. - Rat Genome Database

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Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells.

Authors: Nusser, Z  Sieghart, W  Benke, D  Fritschy, J M  Somogyi, P 
Citation: Nusser Z, etal., Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11939-44.
RGD ID: 13702157
Pubmed: PMID:8876241   (View Abstract at PubMed)
PMCID: PMC38162   (View Article at PubMed Central)

Hippocampal pyramidal cells, receiving domain specific GABAergic inputs, express up to 10 different subunits of the gamma-aminobutyric acid type A (GABAA) receptor, but only 3 different subunits are needed to form a functional pentameric channel. We have tested the hypothesis that some subunits are selectively located at subsets of GABAergic synapses. The alpha 1 subunit has been found in most GABAergic synapses on all postsynaptic domains of pyramidal cells. In contrast, the alpha 2 subunit was located only in a subset of synapses on the somata and dendrites, but in most synapses on axon initial segments innervated by axo-axonic cells. The results demonstrate that molecular specialization in the composition of postsynaptic GABAA receptor subunits parallels GABAergic cell specialization in targeting synapses to a specific domain of postsynaptic cortical neurons.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gabra1RatGABA-ergic synapse is_active_inIDA PMID:8876241SynGO 
Gabra2RatGABA-ergic synapse is_active_inIDA PMID:8876241SynGO 
Gabra1Ratpostsynaptic specialization membrane is_active_inIDA PMID:8876241SynGO 
Gabra2Ratpostsynaptic specialization membrane is_active_inIDA PMID:8876241SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Gabra1  (gamma-aminobutyric acid type A receptor subunit alpha 1)
Gabra2  (gamma-aminobutyric acid type A receptor subunit alpha 2)


Additional Information