RGD Reference Report - Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis. - Rat Genome Database

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Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis.

Authors: Gori, Anna Maria  Giusti, Betti  Piccardi, Benedetta  Nencini, Patrizia  Palumbo, Vanessa  Nesi, Mascia  Nucera, Antonia  Pracucci, Giovanni  Tonelli, Paolina  Innocenti, Eleonora  Sereni, Alice  Sticchi, Elena  Toni, Danilo  Bovi, Paolo  Guidotti, Mario  Tola, Maria Rosaria  Consoli, Domenico  Micieli, Giuseppe  Tassi, Rossana  Orlandi, Giovanni  Sessa, Maria  Perini, Francesco  Delodovici, Maria Luisa  Zedde, Maria Luisa  Massaro, Francesca  Abbate, Rosanna  Inzitari, Domenico 
Citation: Gori AM, etal., J Cereb Blood Flow Metab. 2017 Sep;37(9):3253-3261. doi: 10.1177/0271678X17695572. Epub 2017 Mar 7.
RGD ID: 13702087
Pubmed: PMID:28266892   (View Abstract at PubMed)
PMCID: PMC5584701   (View Article at PubMed Central)
DOI: DOI:10.1177/0271678X17695572   (Journal Full-text)

Inflammatory mediators and metalloproteinases are altered in acute ischemic stroke (AIS) and play a detrimental effect on clinical severity and hemorrhagic transformation of the ischemic brain lesion. Using data from the Italian multicenter observational MAGIC (MArker bioloGici nell'Ictus Cerebrale) Study, we evaluated the effect of inflammatory and metalloproteinases profiles on three-month functional outcome, hemorrhagic transformation and mortality in 327 patients with AIS treated with intravenous thrombolys in according to SITS-MOST (Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy) criteria. Circulating biomarkers were assessed at baseline and 24¿h after thrombolysis. Adjusting for age, sex, baseline glycemia and National Institute of Health Stroke Scale, history of atrial fibrillation or congestive heart failure, and of inflammatory diseases or infections, baseline alpha-2macroglobulin (A2M), baseline serum amyloid protein (SAP) and pre-post tissue-plasminogen activator (tPA) variations (¿) of metalloproteinase 9, remained significantly and independently associated with three-month death [OR (95% CI):A2M:2.99 (1.19-7.53); SAP:5.46 (1.64-18.74); ¿metalloproteinase 9:1.60 (1.12-2.27)]. The addition of baseline A2M and ¿metalloproteinase 9 or baseline SAP and ¿metalloproteinase 9 (model-2 or model-3) to clinical variables (model-1) significantly improved the area under curve for prediction of death [model-2 with A2M: p¿=¿0.0205; model-3 with SAP: p¿=¿0.001]. In conclusion, among AIS patients treated with thrombolysis, circulating A2M, SAP and ¿metalloproteinase 9 are independent markers of poor outcome. These results may prompt controlled clinical research about agents antagonizing their effect.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cerebral infarction disease_progressionIEP 13702087 RGD 
cerebral infarction disease_progressionISOA2M (Homo sapiens)13702087; 13702087 RGD 

Objects Annotated

Genes (Rattus norvegicus)
A2m  (alpha-2-macroglobulin)

Genes (Mus musculus)
A2m  (alpha-2-macroglobulin)

Genes (Homo sapiens)
A2M  (alpha-2-macroglobulin)


Additional Information