RGD Reference Report - APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers. - Rat Genome Database

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APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers.

Authors: Kariola, Reetta  Abdel-Rahman, Wael M  Ollikainen, Miina  Butzow, Ralf  Peltomäki, Päivi  Nyström, Minna 
Citation: Kariola R, etal., Fam Cancer. 2005;4(2):187-90. doi: 10.1007/s10689-004-6130-4.
RGD ID: 13673917
Pubmed: PMID:15951972   (View Abstract at PubMed)
DOI: DOI:10.1007/s10689-004-6130-4   (Journal Full-text)


OBJECTIVE: The adenomatous polyposis coli (APC) and beta-catenin (CTNNB1) genes are the two major components of the Wnt signaling pathway that has been shown to play an important role in the formation of certain cancers. The overactivation of the pathway, which results in abnormal accumulation of beta-catenin protein in nuclei, contributes to most colorectal cancers (CRCs), both sporadic and hereditary, as well as sporadic endometrial cancers (ECs). Here, we studied the involvement of APC and beta-catenin in hereditary nonpolyposis colorectal cancer (HNPCC)-related ECs, and compared the expression patterns to those in HNPCC-related CRCs.
MATERIALS AND METHODS: Nineteen ECs and 31 CRCs derived from HNPCC patients were immunohistochemically stained with anti-APC- and anti-beta-catenin-antibodies.
RESULTS: Tumor-specific loss of APC was observed in 16 of endometrial cancers (3 of 19) and in 39 of colorectal cancers (12 of 31). Consistently, the loss of APC expression was associated with nuclear beta-catenin staining. Altogether, aberrant beta-catenin localization was observed in 53 of ECs (10 of 19) as compared to 84 of CRCs (26 of 31) (P=0.02).
CONCLUSION: Our results suggest a frequent overactivation of the Wnt signaling pathway in hereditary endometrial cancer. In accordance with studies on sporadic cancers, abnormal accumulation of beta-catenin protein in nuclei occurred much less frequently in HNPCC-related ECs than CRCs, which may reflect organ-specific differences in their pathogenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
endometrial cancer  IEP 13673917protein:increased expression:endometrium (human)RGD 
endometrial cancer  ISOAPC (Homo sapiens)13673917; 13673917protein:increased expression:endometrium (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apc  (APC regulator of WNT signaling pathway)

Genes (Mus musculus)
Apc  (APC, WNT signaling pathway regulator)

Genes (Homo sapiens)
APC  (APC regulator of WNT signaling pathway)


Additional Information