RGD Reference Report - Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure. - Rat Genome Database

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Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure.

Authors: Kasahara, Yoshiyuki  Takayanagi, Yuki  Kawada, Teruo  Itoi, Keiichi  Nishimori, Katsuhiko 
Citation: Kasahara Y, etal., Biosci Biotechnol Biochem. 2007 Dec;71(12):3122-6. doi: 10.1271/bbb.70498. Epub 2007 Dec 7.
RGD ID: 13673865
Pubmed: PMID:18071238   (View Abstract at PubMed)
DOI: DOI:10.1271/bbb.70498   (Journal Full-text)

We analyzed temperature homeostasis in oxytocin-deficient (Oxt(-/-)) mice and found that Oxt(-/-) mice exhibited lower body temperatures than wild-type animals when they were exposed to cold. Oxt(-/-) mice also showed slightly more weight gain, but there were no obvious differences in the morphology of white and brown adipose tissues as between wild-type and Oxt(-/-) mice. In cold-exposed conditions, oxytocin neurons containing c-Fos immunoreactivity existed in the paraventricular nucleus of the hypothalamus. These results suggest that the central oxytocin neurons constitute part of the thermoregulatory system involved in maintaining body temperature in cold environments.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of cold-induced thermogenesis involved_inISSUniProtKB:P3545413673865PMID:18071238YuBioLab 

Objects Annotated

Genes (Rattus norvegicus)
Oxt  (oxytocin/neurophysin I prepropeptide)


Additional Information