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Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure.

Authors: Kasahara, Yoshiyuki  Takayanagi, Yuki  Kawada, Teruo  Itoi, Keiichi  Nishimori, Katsuhiko 
Citation: Kasahara Y, etal., Biosci Biotechnol Biochem. 2007 Dec;71(12):3122-6. doi: 10.1271/bbb.70498. Epub 2007 Dec 7.
Pubmed: (View Article at PubMed) PMID:18071238
DOI: Full-text: DOI:10.1271/bbb.70498

We analyzed temperature homeostasis in oxytocin-deficient (Oxt(-/-)) mice and found that Oxt(-/-) mice exhibited lower body temperatures than wild-type animals when they were exposed to cold. Oxt(-/-) mice also showed slightly more weight gain, but there were no obvious differences in the morphology of white and brown adipose tissues as between wild-type and Oxt(-/-) mice. In cold-exposed conditions, oxytocin neurons containing c-Fos immunoreactivity existed in the paraventricular nucleus of the hypothalamus. These results suggest that the central oxytocin neurons constitute part of the thermoregulatory system involved in maintaining body temperature in cold environments.


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RGD Object Information
RGD ID: 13673865
Created: 2018-06-23
Species: All species
Last Modified: 2018-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.