RGD Reference Report - FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. - Rat Genome Database

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FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance.

Authors: Cederberg, A  Grønning, L M  Ahrén, B  Taskén, K  Carlsson, P  Enerbäck, S 
Citation: Cederberg A, etal., Cell. 2001 Sep 7;106(5):563-73.
RGD ID: 13673851
Pubmed: PMID:11551504   (View Abstract at PubMed)

Obesity, hyperlipidemia, and insulin resistance are common forerunners of type 2 diabetes mellitus. We have identified the human winged helix/forkhead transcription factor gene FOXC2 as a key regulator of adipocyte metabolism. Increased FOXC2 expression, in adipocytes, has a pleiotropic effect on gene expression, which leads to a lean and insulin sensitive phenotype. FOXC2 affects adipocyte metabolism by increasing the sensitivity of the beta-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of adipocyte PKA holoenzyme composition. Increased FOXC2 levels, induced by high fat diet, seem to counteract most of the symptoms associated with obesity, including hypertriglyceridemia and diet-induced insulin resistance--a likely consequence hereof would be protection against type 2 diabetes.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Foxc2Ratnegative regulation of cold-induced thermogenesis involved_inISSUniProtKB:Q99958PMID:11551504YuBioLab 

Objects Annotated

Genes (Rattus norvegicus)
Foxc2  (forkhead box C2)


Additional Information