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The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice.

Authors: Szentirmai, Eva  Kap├ís, Levente  Sun, Yuxiang  Smith, Roy G  Krueger, James M 
Citation: Szentirmai E, etal., Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14069-74. doi: 10.1073/pnas.0903090106. Epub 2009 Aug 4.
Pubmed: (View Article at PubMed) PMID:19666521
DOI: Full-text: DOI:10.1073/pnas.0903090106

Peptidergic mechanisms controlling feeding, metabolism, thermoregulation, and sleep overlap in the hypothalamus. Low ambient temperatures and food restriction induce hypothermic (torpor) bouts and characteristic metabolic and sleep changes in mice. We report that mice lacking the preproghrelin gene, but not those lacking the ghrelin receptor, have impaired abilities to manifest and integrate normal sleep and thermoregulatory responses to metabolic challenges. In response to fasting at 17 degrees C (a subthermoneutral ambient temperature), preproghrelin knockout mice enter hypothermic bouts associated with reduced sleep, culminating in a marked drop in body temperature to near-ambient levels. Prior treatment with obestatin, another preproghrelin gene product, attenuates the hypothermic response of preproghrelin knockout mice. Results suggest that obestatin is a component in the coordinated regulation of metabolism and sleep during torpor.


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RGD Object Information
RGD ID: 13673842
Created: 2018-06-23
Species: All species
Last Modified: 2018-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.