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Plac8 is an inducer of C/EBPß required for brown fat differentiation, thermoregulation, and control of body weight.

Authors: Jimenez-Preitner, Maria  Berney, Xavier  Uldry, Marc  Vitali, Alessandra  Cinti, Saverio  Ledford, Julie G  Thorens, Bernard 
Citation: Jimenez-Preitner M, etal., Cell Metab. 2011 Nov 2;14(5):658-70. doi: 10.1016/j.cmet.2011.08.008. Epub 2011 Oct 6.
Pubmed: (View Article at PubMed) PMID:21982742
DOI: Full-text: DOI:10.1016/j.cmet.2011.08.008

Brown adipocytes oxidize fatty acids to produce heat in response to cold or to excessive energy intake; stimulation of brown fat development and function may thus counteract obesity. Brown adipogenesis requires activation of the transcription factor C/EBPß and recruitment of the zinc finger protein Prdm16, but upstream inducers of these proteins are incompletely defined. Here, we show that genetic inactivation of Plac8, a gene encoding an evolutionarily conserved protein, induces cold intolerance, and late-onset obesity, as well as abnormal morphology and impaired function of brown adipocytes. Using brown preadipocyte lines we show that Plac8 is required for brown fat differentiation, that its overexpression induces C/EBPß and Prdm16, and that upon induction of differentiation Plac8 associates with C/EBPß and binds to the C/EBPß promoter to induce its transcription. Thus, Plac8 is a critical upstream regulator of brown fat differentiation and function that acts, at least in part, by inducing C/EBPß expression.


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RGD Object Information
RGD ID: 13673829
Created: 2018-06-23
Species: All species
Last Modified: 2018-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.