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Role of the circadian clock gene Per2 in adaptation to cold temperature.

Authors: Chappuis, Sylvie  Ripperger, J├╝rgen Alexander  Schnell, Anna  Rando, Gianpaolo  Jud, Corinne  Wahli, Walter  Albrecht, Urs 
Citation: Chappuis S, etal., Mol Metab. 2013 May 10;2(3):184-93. doi: 10.1016/j.molmet.2013.05.002. eCollection 2013.
Pubmed: (View Article at PubMed) PMID:24049733
DOI: Full-text: DOI:10.1016/j.molmet.2013.05.002

Adaptive thermogenesis allows mammals to resist to cold. For instance, in brown adipose tissue (BAT) the facultative uncoupling of the proton gradient from ATP synthesis in mitochondria is used to generate systemic heat. However, this system necessitates an increase of the Uncoupling protein 1 (Ucp1) and its activation by free fatty acids. Here we show that mice without functional Period2 (Per2) were cold sensitive because their adaptive thermogenesis system was less efficient. Upon cold-exposure, Heat shock factor 1 (HSF1) induced Per2 in the BAT. Subsequently, PER2 as a co-activator of PPARα increased expression of Ucp1. PER2 also increased Fatty acid binding protein 3 (Fabp3), a protein important to transport free fatty acids from the plasma to mitochondria to activate UCP1. Hence, in BAT PER2 is important for the coordination of the molecular response of mice exposed to cold by synchronizing UCP1 expression and its activation.

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RGD Object Information
RGD ID: 13673819
Created: 2018-06-23
Species: All species
Last Modified: 2018-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.