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The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes.

Authors: Quesada-López, Tania  Cereijo, Rubén  Turatsinze, Jean-Valery  Planavila, Anna  Cairó, Montserrat  Gavaldà-Navarro, Aleix  Peyrou, Marion  Moure, Ricardo  Iglesias, Roser  Giralt, Marta  Eizirik, Decio L  Villarroya, Francesc 
Citation: Quesada-López T, etal., Nat Commun. 2016 Nov 17;7:13479. doi: 10.1038/ncomms13479.
Pubmed: (View Article at PubMed) PMID:27853148
DOI: Full-text: DOI:10.1038/ncomms13479

The thermogenic activity of brown adipose tissue (BAT) and browning of white adipose tissue are important components of energy expenditure. Here we show that GPR120, a receptor for polyunsaturated fatty acids, promotes brown fat activation. Using RNA-seq to analyse mouse BAT transcriptome, we find that the gene encoding GPR120 is induced by thermogenic activation. We further show that GPR120 activation induces BAT activity and promotes the browning of white fat in mice, whereas GRP120-null mice show impaired cold-induced browning. Omega-3 polyunsaturated fatty acids induce brown and beige adipocyte differentiation and thermogenic activation, and these effects require GPR120. GPR120 activation induces the release of fibroblast growth factor-21 (FGF21) by brown and beige adipocytes, and increases blood FGF21 levels. The effects of GPR120 activation on BAT activation and browning are impaired in FGF21-null mice and cells. Thus, the lipid sensor GPR120 activates brown fat via a mechanism that involves induction of FGF21.

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RGD Object Information
RGD ID: 13673796
Created: 2018-06-23
Species: All species
Last Modified: 2018-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.