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RNA Binding Protein Ybx2 Regulates RNA Stability During Cold-Induced Brown Fat Activation.

Authors: Xu, Dan  Xu, Shaohai  Kyaw, Aung Maung Maung  Lim, Yen Ching  Chia, Sook Yoong  Chee Siang, Diana Teh  Alvarez-Dominguez, Juan R  Chen, Peng  Leow, Melvin Khee-Shing  Sun, Lei 
Citation: Xu D, etal., Diabetes. 2017 Dec;66(12):2987-3000. doi: 10.2337/db17-0655. Epub 2017 Sep 29.
Pubmed: (View Article at PubMed) PMID:28970281
DOI: Full-text: DOI:10.2337/db17-0655

Recent years have seen an upsurge of interest in brown adipose tissue (BAT) to combat the epidemic of obesity and diabetes. How its development and activation are regulated at the posttranscriptional level, however, has yet to be fully understood. RNA binding proteins (RBPs) lie in the center of posttranscriptional regulation. To systemically study the role of RBPs in BAT, we profiled >400 RBPs in different adipose depots and identified Y-box binding protein 2 (Ybx2) as a novel regulator in BAT activation. Knockdown of Ybx2 blocks brown adipogenesis, whereas its overexpression promotes BAT marker expression in brown and white adipocytes. Ybx2-knockout mice could form BAT but failed to express a full thermogenic program. Integrative analysis of RNA sequencing and RNA-immunoprecipitation study revealed a set of Ybx2's mRNA targets, including Pgc1α, that were destabilized by Ybx2 depletion during cold-induced activation. Thus, Ybx2 is a novel regulator that controls BAT activation by regulating mRNA stability.


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RGD Object Information
RGD ID: 13673771
Created: 2018-06-23
Species: All species
Last Modified: 2018-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.