Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat.

Authors: Seki, Takahiro  Hosaka, Kayoko  Lim, Sharon  Fischer, Carina  Honek, Jennifer  Yang, Yunlong  Andersson, Patrik  Nakamura, Masaki  Näslund, Erik  Ylä-Herttuala, Seppo  Sun, Meili  Iwamoto, Hideki  Li, Xuri  Liu, Yizhi  Samani, Nilesh J  Cao, Yihai 
Citation: Seki T, etal., Nat Commun. 2016 Aug 5;7:12152. doi: 10.1038/ncomms12152.
Pubmed: (View Article at PubMed) PMID:27492130
DOI: Full-text: DOI:10.1038/ncomms12152

Cold- and ß3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of endothelial VEGFR2, knockout of the Pdgf-c gene or pharmacological blockade of PDGFR-α impair the WAT-beige transition. We further show that PDGF-CC stimulation upregulates UCP1 expression and acquisition of a beige phenotype in differentiated mouse WAT-PDGFR-α(+) progenitor cells, as well as in human WAT-PDGFR-α(+) adipocytes, supporting the physiological relevance of our findings. Our data reveal a paracrine mechanism by which angiogenic endothelial cells modulate adipocyte metabolism, which may provide new targets for the treatment of obesity and related metabolic diseases.

Annotation

Gene Ontology Annotations
Objects Annotated

Additional Information

 
RGD Object Information
RGD ID: 13673767
Created: 2018-06-23
Species: All species
Last Modified: 2018-06-23
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.