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Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat.

Authors: Seki, Takahiro  Hosaka, Kayoko  Lim, Sharon  Fischer, Carina  Honek, Jennifer  Yang, Yunlong  Andersson, Patrik  Nakamura, Masaki  Näslund, Erik  Ylä-Herttuala, Seppo  Sun, Meili  Iwamoto, Hideki  Li, Xuri  Liu, Yizhi  Samani, Nilesh J  Cao, Yihai 
Citation: Seki T, etal., Nat Commun. 2016 Aug 5;7:12152. doi: 10.1038/ncomms12152.
Pubmed: (View Article at PubMed) PMID:27492130
DOI: Full-text: DOI:10.1038/ncomms12152

Cold- and ß3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of endothelial VEGFR2, knockout of the Pdgf-c gene or pharmacological blockade of PDGFR-α impair the WAT-beige transition. We further show that PDGF-CC stimulation upregulates UCP1 expression and acquisition of a beige phenotype in differentiated mouse WAT-PDGFR-α(+) progenitor cells, as well as in human WAT-PDGFR-α(+) adipocytes, supporting the physiological relevance of our findings. Our data reveal a paracrine mechanism by which angiogenic endothelial cells modulate adipocyte metabolism, which may provide new targets for the treatment of obesity and related metabolic diseases.


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RGD Object Information
RGD ID: 13673767
Created: 2018-06-23
Species: All species
Last Modified: 2018-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.