RGD Reference Report - [Association of ITGA9 gene rs189897 and rs2212020 genotypes and its haplotype with cerebral infarction]. - Rat Genome Database

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[Association of ITGA9 gene rs189897 and rs2212020 genotypes and its haplotype with cerebral infarction].

Authors: Li, Xiang-min  Li, Jing  Zeng, Feng  Yi, Hong 
Citation: Li XM, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2011 Jun;31(7):1142-5.
RGD ID: 13602007
Pubmed: PMID:21764681   (View Abstract at PubMed)


OBJECTIVE: To study the association of ITGA9 gene rs189897 and rs2212020 polymorphisms and its haplotype with the occurrence of cerebral infarction (CI).
METHODS: In the venous blood samples from 250 patients with cerebral infarction and 250 control samples, the genotypes of rs189897 and rs2212020 of ITGA9 gene were identified by PCR-sequencing. SHEsis software was used to analyze the association between the results of genotyping and the occurrence of CI.
RESULTS: The cerebral infarction group and the control groups showed significant differences in the allele and genotype frequencies of rs189897 and rs2212020 (P<0.05). The A-C haplotype was the protective factor against CI, and the subjects with the haplotype had a lowered risk for CI than those without this haplotype (0.13:1).
CONCLUSION: rs189897 and rs2212020 in ITGA9 gene are closely related to CI, and its A-C haplotype is the protective factor against CI.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cerebral infarction susceptibilityIAGP 13602007DNA:SNPs more ...RGD 
cerebral infarction susceptibilityISOITGA9 (Homo sapiens)13602007; 13602007DNA:SNPs more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Itga9  (integrin subunit alpha 9)

Genes (Mus musculus)
Itga9  (integrin alpha 9)

Genes (Homo sapiens)
ITGA9  (integrin subunit alpha 9)


Additional Information