RGD Reference Report - Absence of integrin alpha 7 causes a novel form of muscular dystrophy. - Rat Genome Database

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Absence of integrin alpha 7 causes a novel form of muscular dystrophy.

Authors: Mayer, U  Saher, G  Fässler, R  Bornemann, A  Echtermeyer, F  von der Mark, H  Miosge, N  Pöschl, E  von der Mark, K 
Citation: Mayer U, etal., Nat Genet. 1997 Nov;17(3):318-23. doi: 10.1038/ng1197-318.
RGD ID: 13601979
Pubmed: (View Article at PubMed) PMID:9354797
DOI: Full-text: DOI:10.1038/ng1197-318

Integrin alpha 7 beta 1 is a specific cellular receptor for the basement membrane protein laminin-1 (refs 1,2), as well as for the laminin isoforms -2 and -4 (ref. 3). The alpha 7 subunit is expressed mainly in skeletal and cardiac muscle and has been suggested to be involved in differentiation and migration processes during myogenesis. Three cytoplasmic and two extracellular splice variants that have been described are developmentally regulated and expressed in different sites in the muscle. In adult muscle, the alpha 7A and alpha 7B subunits are concentrated in myotendinous junctions but can also be detected in neuromuscular junctions and along the sarcolemmal membrane. To study the potential involvement of alpha 7 integrin, during myogenesis and its role in muscle integrity and function, we generated a null allele of the alpha 7 gene (Itga7) in the germline of mice by homologous recombination in embryonic stem (ES) cells. Surprisingly, mice homozygous for the mutation are viable and fertile, indicating that the alpha 7 beta 1 integrin is not essential for myogenesis. However, histological analysis of skeletal muscle revealed typical symptoms of a progressive muscular dystrophy starting soon after birth, but with a distinct variability in different muscle types. The observed histopathological changes strongly indicate an impairment of function of the myotendinous junctions. These findings demonstrate that alpha 7 beta 1 integrin represents an indispensable linkage between the muscle fibre and the extracellular matrix that is independent of the dystrophin-dystroglycan complex-mediated interaction of the cytoskeleton with the muscle basement membrane.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Itga7  (integrin subunit alpha 7)

Genes (Mus musculus)
Itga7  (integrin alpha 7)

Genes (Homo sapiens)
ITGA7  (integrin subunit alpha 7)


Additional Information