RGD Reference Report - Identification and characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal RNA methyltransferase. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Identification and characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal RNA methyltransferase.

Authors: Ching, YP  Zhou, HJ  Yuan, JG  Qiang, BQ  Kung Hf, HF  Jin, DY 
Citation: Ching YP, etal., Genomics 2002 Jan;79(1):2-6.
RGD ID: 1359074
Pubmed: PMID:11827451   (View Abstract at PubMed)
DOI: DOI:10.1006/geno.2001.6670   (Journal Full-text)

Cellular RNAs in eukaryotes undergo extensive posttranscriptional modifications, but as yet only a few RNA-modifying enzymes have been identified and characterized. Here we report on the cloning of FTSJ2, a novel human gene encoding a putative RNA methyltransferase. FTSJ2 shares significant sequence homology with FtsJ/RrmJ, a recently identified Escherichia coli 23S rRNA uridine-2'-O-methyltransferase. FTSJ2 belongs to a new family of evolutionarily conserved S-adenosylmethionine-binding proteins. The gene FTSJ2 is located on chromosome 7p22 between MAD1L1 and NUDT1. It is 8 kb in length, spanning three exons. Northern blot analysis revealed that the FTSJ2 transcripts are abundant in skeletal muscle, placenta, and heart, as well as in cancer cells. Immunofluorescence staining demonstrated that FTSJ2 protein localizes to the nucleolus. Our results suggest that FTSJ2 is likely a nucleolar RNA methyltransferase involved in eukaryotic RNA processing and modification.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MRM2Humanhomocysteine metabolic pathway   NAS  RGD 
Mrm2Rathomocysteine metabolic pathway   ISOMRM2 (Homo sapiens) RGD 
MRM2Humanmethionine cycle/metabolic pathway   TAS  RGD 
Mrm2Ratmethionine cycle/metabolic pathway   ISOMRM2 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Mrm2  (mitochondrial rRNA methyltransferase 2)

Genes (Homo sapiens)
MRM2  (mitochondrial rRNA methyltransferase 2)


Additional Information