RGD Reference Report - The POU factor Oct-6 and Schwann cell differentiation. - Rat Genome Database

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The POU factor Oct-6 and Schwann cell differentiation.

Authors: Jaegle, M  Mandemakers, W  Broos, L  Zwart, R  Karis, A  Visser, P  Grosveld, F  Meijer, D 
Citation: Jaegle M, etal., Science 1996 Jul 26;273(5274):507-10.
RGD ID: 1358790
Pubmed: PMID:8662541   (View Abstract at PubMed)

The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6(-/-) mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

Objects referenced in this article
Gene Nppc natriuretic peptide type C Mus musculus
Gene Pou3f1 POU domain, class 3, transcription factor 1 Mus musculus
Gene Pou3f1 POU class 3 homeobox 1 Rattus norvegicus

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