RGD Reference Report - Genetic dissection of neurodegeneration and CNS inflammation. - Rat Genome Database

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Genetic dissection of neurodegeneration and CNS inflammation.

Authors: Olsson, T  Piehl, F  Swanberg, M  Lidman, O 
Citation: Olsson T, etal., J Neurol Sci 2005 Jun 15;233(1-2):99-108.
RGD ID: 1358768
Pubmed: PMID:15894332   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jns.2005.03.020   (Journal Full-text)

Inflammation and neurodegeneration characterize multiple sclerosis, as well as many other diseases of the central nervous system (CNS). The understanding of the molecular pathways that regulate these processes is of fundamental importance for the development of new therapies. Nerve lesions paradigms in animals can serve as important tools to dissect central features of human CNS disease and by using these models certain key regulators have also been identified. However, our knowledge of how aspects of neurodegeneration and CNS inflammation are regulated on a genomic level is very limited. Such knowledge may help to unravel disease mechanisms. By using a standardized nerve trauma model, ventral root avulsion (VRA), in a series of inbred rat strains we here demonstrate a potent genetic regulation of the degree of neuron death and glial activation. Genome wide mapping of these phenotypes in experimental rat strain crosses identifies several quantitative trait loci (QTLs) controlling nerve lesion-induced nerve cell death, local T cell accumulation and expression of MHC class II on microglia. This approach may lead to the identification of evolutionary conserved genetic polymorphisms in key controlling genes, which can serve as prime candidates for association studies in several human CNS diseases.



Objects referenced in this article
QTL Neudeg1 Neurodegradation QTL 1 Rattus norvegicus
QTL Neudeg2 Neurodegradation QTL 2 Rattus norvegicus
QTL Neuinf1 Neuroinflammation QTL 1 Rattus norvegicus
QTL Neuinf2 Neuroinflammation QTL 2 Rattus norvegicus

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