RGD Reference Report - Association between the low molecular weight cytosolic acid phosphatase gene ACP1*A and comorbid features of Tourette syndrome. - Rat Genome Database

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Association between the low molecular weight cytosolic acid phosphatase gene ACP1*A and comorbid features of Tourette syndrome.

Authors: Bottini, N  MacMurray, J  Rostamkani, M  McGue, M  Iacono, WG  Comings, DE 
Citation: Bottini N, etal., Neurosci Lett 2002 Sep 20;330(2):198-200.
RGD ID: 1358577
Pubmed: PMID:12231445   (View Abstract at PubMed)

Protein tyrosine phosphatases have been implicated in the regulation of serotonergic and dopaminergic activity in the central nervous system. In a recent study we found that nonA/nonA homozygosity at the locus codifying for the low molecular weight protein tyrosine phosphatase (ACP1) was associated with increased rates of major depression in males (P<0.00003), suggesting that the ACP1*A single nucleotide polymorphism (SNP) may be an important marker for psychopathology. In the present study we examined the ACP1*A SNP in 539 screened controls and 184 male Tourette syndrome (TS) cases, all Caucasians of European descent. The frequency of the nonA allele was markedly increased in TS cases relative to controls (P<0.0005), but this difference was restricted to cases with comorbid attention-deficit hyperactivity disorder (P<0.0001) and conduct disorder (P<0.0002), while having little relevance to TS itself.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
attention deficit hyperactivity disorder  IAGP 1358577associated with Tourette Syndrome more ...RGD 
attention deficit hyperactivity disorder  ISOACP1 (Homo sapiens)1358577; 1358577associated with Tourette Syndrome more ...RGD 
conduct disorder  IAGP 1358577associated with Tourette Syndrome more ...RGD 
conduct disorder  ISOACP1 (Homo sapiens)1358577; 1358577associated with Tourette Syndrome more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Acp1  (acid phosphatase 1)

Genes (Mus musculus)
Acp1  (acid phosphatase 1, soluble)

Genes (Homo sapiens)
ACP1  (acid phosphatase 1)


Additional Information