RGD Reference Report - Preliminary phenotypic characterization of the Warsaw High Preferring (WHP) and Warsaw Low Preferring (WLP) lines of rats selectively bred for high and low ethanol consumption. - Rat Genome Database

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Preliminary phenotypic characterization of the Warsaw High Preferring (WHP) and Warsaw Low Preferring (WLP) lines of rats selectively bred for high and low ethanol consumption.

Authors: Dyr, W  Kostowski, W 
Citation: Dyr W and Kostowski W, Pol J Pharmacol 2004 May-Jun;56(3):359-65.
RGD ID: 1358540
Pubmed: PMID:15215567   (View Abstract at PubMed)

The Warsaw High Preferring (WHP) and Warsaw Low Preferring (WLP) lines were bred from Wistar foundation stock to obtain lines of rats that differ in their preference for ethanol (EtOH) solutions. The WHP line has met major criteria for an animal model of alcoholism. The WHP rats voluntarily drink excessive amounts of alcohol while the WLP rats consume negligible amounts of alcohol. These patterns of EtOH consumption are stable in time and independent of the manner of access to EtOH solutions. Notably, when exposed to the increasing EtOH concentrations both WHP and unselected Wistar rats gradually increased total EtOH intake. In contrast, WLP rats when exposed to the increasing concentrations of EtOH consumed almost negligible amounts of EtOH. Furthermore, the WHP rats show an increased responsiveness to the stimulatory effects of low dose of EtOH.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
WHPRatalcohol use disorder  IAGP compared to WLP and Wistar ratsRGD 
WLPRatalcohol use disorder  IAGP controls and compared to WHP ratsRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
WHPRatalcohol preference  IAGP compared to WLP ratsRGD 
WLPRatdecreased alcohol consumption  IAGP compared to WHP ratsRGD 
WHPRatdecreased food intake  IAGP compared to WLP ratsRGD 
WHPRatenhanced behavioral response to alcohol  IAGP compared to WLP more ...RGD 
WHPRatincreased alcohol consumption  IAGP compared to WLP ratsRGD 
WLPRatlow alcohol preference  IAGP compared to WHPRGD 
Objects Annotated

Strains
WHP  (Warsaw High Prefering)
WLP  (Warsaw Low Prefering)


Additional Information