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Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3).

Authors: Mynett-Johnson, L  Murphy, V  McCormack, J  Shields, DC  Claffey, E  Manley, P  McKeon, P 
Citation: Mynett-Johnson L, etal., Biol Psychiatry 1998 Jul 1;44(1):47-51.
Pubmed: (View Article at PubMed) PMID:9646882

BACKGROUND: Disturbances in central nervous system Na+, K+ adenosine triphosphatase (ATPase) activity have previously been proposed as being involved in the pathophysiology of bipolar mood disorder. METHODS: We have examined one particular alpha subunit of this enzyme for allelic association in a sample of 85 Irish bipolar patients and 85 matched controls. RESULTS: There was evidence for an overall allelic association between the disease and a dinucleotide polymorphism within the ATP1A3 gene (p = .022). Subjects were then analyzed on the basis of a number of criteria, and the significance of the association increased when cases were divided based on the nature of the first episode. Patients who presented with a depressive episode first showed a significant association (p = .001) with this polymorphism. CONCLUSIONS: The results presented here provide preliminary evidence of an association between bipolar disorder and an alpha subunit of Na+, K+ ATPase, the expression of which predominates in the brain.


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RGD Object Information
RGD ID: 1358437
Created: 2005-06-12
Species: All species
Last Modified: 2005-06-12
Status: ACTIVE


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