RGD Reference Report - Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis. - Rat Genome Database

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Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis.

Authors: Zouali, H  Faure-Delanef, L  Lucotte, G 
Citation: Zouali H, etal., Mult Scler 1999 Apr;5(2):134-6.
RGD ID: 1358408
Pubmed: PMID:10335523   (View Abstract at PubMed)

We have used a PCR based method to analyze allelic frequencies in a (TG)n(AG)m microsatellite marker located in the first intron of the apolipoprotein C-II gene in French MS patients and controls. Samples were collected from 74 MS patients and from 102 controls. The distribution of microsatellite alleles differed between patients and controls (chi 2 = 7.82), showing a significant effect (P < 0.04) with MS due to the increased frequency of the allele 6 and a decrease frequency (P < 0.03) of allele I. Our study confirms that the apolipoprotein C-II region may influence susceptibility to MS.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
multiple sclerosis  IAGP 1358408 RGD 
multiple sclerosis  ISOAPOC2 (Homo sapiens)1358408; 1358408 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoc2  (apolipoprotein C2)

Genes (Mus musculus)
Apoc2  (apolipoprotein C2)

Genes (Homo sapiens)
APOC2  (apolipoprotein C2)


Additional Information