RGD Reference Report - A speed congenic rat strain bearing the tongue cancer susceptibility locus Tscc1 from Dark-Agouti rats. - Rat Genome Database

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A speed congenic rat strain bearing the tongue cancer susceptibility locus Tscc1 from Dark-Agouti rats.

Authors: Hirano, M  Tanuma, JI  Hirayama, Y  Ohyama, M  Semba, I  Wakusawa, S  Shisa, H  Hiai, H  Kitano, M 
Citation: Hirano M, etal., Cancer Lett 2005 May 2;.
RGD ID: 1358147
Pubmed: PMID:15876484   (View Abstract at PubMed)
DOI: DOI:10.1016/j.canlet.2005.01.043   (Journal Full-text)

We previously reported that Dark-Agouti (DA) rats are highly susceptible to 4-nitroquinoline 1-oxide (4NQO)-induced tongue cancer (TC), whereas Wistar/Furth (WF) rats are barely susceptible. Linkage analysis of reciprocal (DAxWF)F2 rats demonstrated five quantitative trait loci, Tongue squamous cell carcinoma 1-5 (Tscc1-5) determining the size and number of the TCs. The major susceptibility locus Tscc1 is mapped on rat chromosome 19. In the present study, we used a marker-assisted speed congenic procedure to construct WF.DA-Tscc1 (WF-T1D) rats, i.e. WF rats carrying a DA-derived Tscc1 chromosomal segment, and evaluated the effect of a single Tscc1 on 4NQO-induced tongue carcinogenesis. In WF-T1D rats, the incidence, number and size of 4NQO-induced TCs were significantly higher than those in WF rats, indicating that the introgressed segment contains one of the susceptibility loci for 4NQO-induced TCs from DA rats. Detection of a single nucleotide polymorphism in NQO1, one of the Tscc1 candidate genes, enabled us to map NQO1 in the Tscc1 segment between D19Wox8 and D19Wox7 on chromosome 19. Possible relevance of NQO1 polymorphism to TC susceptibility is discussed.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Tongue Neoplasms  IAGP 1358147 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
increased tongue tumor incidence  IDA 1358147 RGD 

Objects Annotated

QTLs
Tcas7  (Tongue tumor susceptibility QTL 7)

Objects referenced in this article
QTL Tcas1 Tongue tumor susceptibility QTL 1 Rattus norvegicus

Additional Information