RGD Reference Report - Severe hypertension caused by alleles from normotensive Lewis for a quantitative trait locus on Chromosome 2. - Rat Genome Database

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Severe hypertension caused by alleles from normotensive Lewis for a quantitative trait locus on Chromosome 2.

Authors: Eliopoulos, V  Dutil, J  Deng, Y  Grondin, M  Deng, AY 
Citation: Eliopoulos V, etal., Physiol Genomics 2005 Apr 12;.
RGD ID: 1358142
Pubmed: PMID:15827238   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00019.2005   (Journal Full-text)

Pursuing fully a suggestion from linkage analysis that there might be a quantitative trait locus (QTL) for blood pressure (BP) in a Chromosome (Chr) 2 region of the Dahl salt-sensitive rat (DSS), four congenic strains were made by replacing various fragments of DSS Chr 2 with those of Lewis (LEW). Consequently, a BP QTL was localized to a segment of around 3 centiMorgan (cM) or near 3 megabases (Mbs) on Chr 2 by comparative congenics. The BPaugmenting alleles of this QTL originated from the LEW rat, a normotensive strain compared to DSS. The dissection of a QTL with such a paradoxical effect illustrated the power of congenics in unearthing a gene hidden in the context of the whole animal system presumably by interactions with other genes. The locus for the angiotensin II receptor AT1B (Agtr1b) is not supported as a candidate gene for the QTL because a congenic strain harboring it did not have an effect on BP. There are approximately 19 known and unknown genes present in the QTLinterval. Among them, no standout candidate genes are reputed to affect BP. Thus the QTL will likely represent a novel gene for BP regulation.



Objects Annotated

QTLs
Bp270  (Blood pressure QTL 270)

Objects referenced in this article
Marker D2Chm229 D2Chm229 Rattus norvegicus
Marker D2Chm149 D2Chm149 Rattus norvegicus
Marker D2Chm296 D2Chm296 Rattus norvegicus
Marker D2Chm280 D2Chm280 Rattus norvegicus
Marker D3Chm238 D3Chm238 Rattus norvegicus
Marker D2Chm278 D2Chm278 Rattus norvegicus
Marker D2Chm172 D2Chm172 Rattus norvegicus
Marker D2Chm191 D2Chm191 Rattus norvegicus
Marker D2Chm277 D2Chm277 Rattus norvegicus
Marker D2Chm192 D2Chm192 Rattus norvegicus
Marker D2Chm294 D2Chm294 Rattus norvegicus
Marker D2Chm299 D2Chm299 Rattus norvegicus
Marker D2Chm289 D2Chm289 Rattus norvegicus
Marker D2Chm233 D2Chm233 Rattus norvegicus
Marker D2Chm175 D2Chm175 Rattus norvegicus
Marker D2Chm145 D2Chm145 Rattus norvegicus
Strain SS.LEW-(D2Rat199-D2Mco17)/Ayd null Rattus norvegicus
Strain SS.LEW-(Prlr-D2Rat143)/Ayd null Rattus norvegicus

Additional Information