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A new rat model for studying the calpain-calpastatin system.

Authors: Soldati, LP  Barber, BR  Salardi, S  Molinari, I  Bianchi, G 
Citation: Soldati LP, etal., Lab Anim 1995 Oct;29(4):420-6.
Pubmed: (View Article at PubMed) PMID:8558825

A recombinant rat strain--Milan low-calpastatin strain (MLCS)--was derived from Milan hypertensive (MHS/Gib) and Milan normotensive (MNS/Gib) strains. The MLCS rats have normal blood pressure and low calpastatin activity, and this strain is proposed as a model for studies of the calpain-calpastatin system, which is involved in important cellular mechanisms. Calpastatin polymorphism was observed in 10 different strains of laboratory rats and a single locus hypothesis is suggested as the mode of inheritance.

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