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Association of CACNG6 polymorphisms with aspirin-intolerance asthmatics in a Korean population.

Authors: Lee, Jin Sol  Kim, Jeong-Hyun  Bae, Joon Seol  Kim, Jason Yongha  Park, Tae Joon  Pasaje, Charisse Flerida  Park, Byung-Lae  Cheong, Hyun Sub  Uh, Soo-Taek  Park, Jong-Sook  Jang, An-Soo  Kim, Mi-Kyeong  Choi, Inseon S  Park, Choon-Sik  Shin, Hyoung Doo 
Citation: Lee JS, etal., BMC Med Genet. 2010 Sep 23;11:138. doi: 10.1186/1471-2350-11-138.
Pubmed: (View Article at PubMed) PMID:20860846
DOI: Full-text: DOI:10.1186/1471-2350-11-138

BACKGROUND: Aspirin-intolerant asthma (AIA) occurs in the lower and upper airways through excessive production of leukotrienes upon administration of non-steroidal anti-inflammatory drugs (NSAIDs). One of the three symptoms of AIA is nasal polyposis, a chronic inflammatory disease that is related to the function of calcium ion in recruitment of immune cells during airway inflammation. It has been implicated that bronchodilation in the airway is related to Ca(2+) regulation. The calcium channel, voltage-dependent, gamma subunit 6 (CACNG6) gene encodes a protein that stabilizes the calcium channel.
METHODS: To study the associations between AIA and polymorphisms in CACNG6 gene, eight variants were genotyped in 102 AIA cases and 429 aspirin-tolerant asthma (ATA) controls. Logistic analyses were used to evaluate the associations of CACNG6 polymorphisms with AIA.
RESULTS: Statistical analyses revealed that a single nucleotide polymorphism (SNP; rs192808C > T; P = 0.0004, Pcorr = 0.0029, OR = 2.88 in co-dominant model; P = 0.0005, Pcorr = 0.0036, OR = 2.99 in dominant model) in intron and a haplotype unique to this variant (CACNG6_BL1_ht6; P = 0.003, Pcorr = 0.02, OR = 2.57 in co-dominant model, P = 0.001, Pcorr = 0.0087, OR = 2.81 in dominant model) were significantly associated with the risk of AIA.
CONCLUSIONS: Our results suggest that the CACNG6 variants might be associated with the risk of AIA in a Korean population.


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RGD Object Information
RGD ID: 13524562
Created: 2018-04-20
Species: All species
Last Modified: 2018-04-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.