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Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins.

Authors: Tomita, Susumu  Chen, Lu  Kawasaki, Yoshimi  Petralia, Ronald S  Wenthold, Robert J  Nicoll, Roger A  Bredt, David S 
Citation: Tomita S, etal., J Cell Biol. 2003 May 26;161(4):805-16. doi: 10.1083/jcb.200212116.
Pubmed: (View Article at PubMed) PMID:12771129
DOI: Full-text: DOI:10.1083/jcb.200212116

Functional expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in cerebellar granule cells requires stargazin, a member of a large family of four-pass transmembrane proteins. Here, we define a family of transmembrane AMPA receptor regulatory proteins (TARPs), which comprise stargazin, gamma-3, gamma-4, and gamma-8, but not related proteins, that mediate surface expression of AMPA receptors. TARPs exhibit discrete and complementary patterns of expression in both neurons and glia in the developing and mature central nervous system. In brain regions that express multiple isoforms, such as cerebral cortex, TARP-AMPA receptor complexes are strictly segregated, suggesting distinct roles for TARP isoforms. TARPs interact with AMPA receptors at the postsynaptic density, and surface expression of mature AMPA receptors requires a TARP. These studies indicate a general role for TARPs in controlling synaptic AMPA receptors throughout the central nervous system.


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RGD Object Information
RGD ID: 13515082
Created: 2018-04-03
Species: All species
Last Modified: 2018-04-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.