RGD Reference Report - The stargazin C terminus encodes an intrinsic and transferable membrane sorting signal. - Rat Genome Database

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The stargazin C terminus encodes an intrinsic and transferable membrane sorting signal.

Authors: Bedoukian, Matthew A  Whitesell, Jennifer D  Peterson, Erik J  Clay, Colin M  Partin, Kathryn M 
Citation: Bedoukian MA, etal., J Biol Chem. 2008 Jan 18;283(3):1597-600. doi: 10.1074/jbc.M708141200. Epub 2007 Nov 6.
RGD ID: 13515070
Pubmed: (View Article at PubMed) PMID:17986442
DOI: Full-text: DOI:10.1074/jbc.M708141200

Activity-dependent plasticity of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors is regulated by their auxiliary subunit, stargazin. Association with stargazin enhances alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor surface expression and modifies the receptor's biophysical properties. Fusing the cytoplasmic C terminus of stargazin to the C-terminal domains of either GluR1 or the gonadotropin-releasing hormone receptor permits efficient trafficking from the endoplasmic reticulum and sorting to the basolateral membrane without altering other properties of either receptor.

Annotation

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Cacng2  (calcium voltage-gated channel auxiliary subunit gamma 2)


Additional Information