RGD Reference Report - Low differentiated microvascular density and low expression of platelet-derived growth factor-BB (PDGF-BB) predict distant metastasis and poor prognosis in clear cell renal cell carcinoma.

General

Low differentiated microvascular density and low expression of platelet-derived growth factor-BB (PDGF-BB) predict distant metastasis and poor prognosis in clear cell renal cell carcinoma.
Authors:	Qi, Lifeng Du, Jun Zhang, Zhenting Diao, Lei Chen, Xusheng Yao, Xin
Citation:	Qi L, etal., BJU Int. 2013 Aug;112(4):E415-23. doi: 10.1111/bju.12191.
RGD ID:	13506650
Pubmed:	PMID:23879920 (View Abstract at PubMed)
DOI:	DOI:10.1111/bju.12191 (Journal Full-text)
OBJECTIVE: To examine the prognostic significance of the expression of platelet-derived growth factor-BB (PDGF-BB) and differentiated microvascular density (MVD) in patients with clear cell renal cell carcinoma (ccRCC). PATIENTS AND METHODS: We used the vascular marker cluster of differentiation 34 (CD34) to identify tumour blood vessels. The expression of PDGF-BB and CD34 was detected by immunohistochemistry (IHC) in tissue microarrays (TMAs) from 100 ccRCCs. Prognostic effects of individual parameters were calculated using Cox regression models and Harrell's concordance index (c-index). RESULTS: Higher grade and more advanced stage ccRCCs had significantly less PDGF-BB expression and differentiated MVD (P < 0.05). Higher PDGF-BB expression was an independent prognostic factor for longer survival, and moreover, the final model built by the addition of PDGF-BB expression improved the predictive accuracy for disease-free survival (c-index 0.707) compared with the clinicopathological-based model (c-index 0.695). PDGF-BB expression was positively associated with differentiated MVD assessed by Spearman correlation and factor analysis (r = 0.634, P < 0.001). CONCLUSION: PDGF-BB is as a novel and promising prognostic marker and antiangiogenic therapeutic target for the treatment of ccRCC.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
clear cell renal cell carcinoma	disease_progression	IDA		13506650		RGD
clear cell renal cell carcinoma	disease_progression	ISO	PDGFB (Homo sapiens)	13506650; 13506650		RGD

Objects Annotated

Genes (Rattus norvegicus)

Pdgfb (platelet derived growth factor subunit B)

Genes (Mus musculus)

Pdgfb (platelet derived growth factor, B polypeptide)

Genes (Homo sapiens)

PDGFB (platelet derived growth factor subunit B)

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Low differentiated microvascular density and low expression of platelet-derived growth factor-BB (PDGF-BB) predict distant metastasis and poor prognosis in clear cell renal cell carcinoma.