RGD Reference Report - Alzheimer's disease-like pathology in senescence-accelerated OXYS rats can be partially retarded with mitochondria-targeted antioxidant SkQ1. - Rat Genome Database

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Alzheimer's disease-like pathology in senescence-accelerated OXYS rats can be partially retarded with mitochondria-targeted antioxidant SkQ1.

Authors: Stefanova, Natalia A  Muraleva, Natalia A  Skulachev, Vladimir P  Kolosova, Nataliya G 
Citation: Stefanova NA, etal., J Alzheimers Dis. 2014;38(3):681-94. doi: 10.3233/JAD-131034.
RGD ID: 13503332
Pubmed: PMID:24047616   (View Abstract at PubMed)
DOI: DOI:10.3233/JAD-131034   (Journal Full-text)

We previously showed that mitochondria-targeted antioxidant SkQ1 (plastoquinonyl-decyltriphenylphosphonium) at nanomolar concentrations is capable of preventing and slowing down some cerebral dysfunctions in accelerated-senescence OXYS rats. Here we demonstrate that OXYS rats develop behavior, learning, and memory deficits against a background of neurodegeneration signs detected by magnetic resonance tomography and amyloid-ß (Aß) pathology similar to those seen in Alzheimer's disease (AD). Long-term treatment with SkQ1 (250 nmol/kg body weight daily from the age of 1.5 to 23 months) reduced the age-related alterations in behavior and spatial memory deficit in Morris water maze in OXYS and Wistar rats. Furthermore, this is the first report that SkQ1 treatment slows down pathological accumulation of AßPP, Aß, and hyperphosphorylation of tau-protein in OXYS rats, as well as age-dependent changes in healthy Wistar rats. Our results support the possibility of using the OXYS strain as a rat model of AD-like pathology. It seems probable that the mitochondria-targeted antioxidant SkQ1 can be a good prophylactic strategy to maintain brain health and to treat AD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IAGP 13503332 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
amyloid beta deposits  IAGP 13503332 RGD 
demyelination  IAGP 13503332 RGD 
enlarged lateral ventricles  IAGP 13503332 RGD 
Objects Annotated

Strains
OXYS/Nov  (NA)


Additional Information