RGD Reference Report - Association of Fc¿RIIa Polymorphism with Clinical Outcome of Dengue Infection: First Insight from Pakistan. - Rat Genome Database

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Association of Fc¿RIIa Polymorphism with Clinical Outcome of Dengue Infection: First Insight from Pakistan.

Authors: Mohsin, Saima Naz  Mahmood, Saqib  Amar, Ali  Ghafoor, Farkhanda  Raza, Syed Mohsin  Saleem, Mahjabeen 
Citation: Mohsin SN, etal., Am J Trop Med Hyg. 2015 Oct;93(4):691-6. doi: 10.4269/ajtmh.15-0199. Epub 2015 Aug 3.
RGD ID: 13463456
Pubmed: PMID:26240159   (View Abstract at PubMed)
PMCID: PMC4596583   (View Article at PubMed Central)
DOI: DOI:10.4269/ajtmh.15-0199   (Journal Full-text)

Dengue illness has been a major health concern in Pakistan during the last decade. Dengue infection can result in a spectrum of clinically distinct outcomes, ranging from asymptomatic infection to potentially life-threatening forms of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). A single-nucleotide polymorphism in FcγRIIa (rs1801274) results in altered affinity of the receptor for different subclasses of immunoglobulin G, and is a key player in determining the susceptibility to or protection from severe clinical infection of dengue. In this study, we analyzed the allelic and genotypic distribution of rs1801274 in subjects of Pakistani origin with subclinical dengue infection (n = 40), dengue fever (DF) (n = 40), and DHF/DSS (n = 30). We found that HH homozygotes and heterozygotes were significantly more likely to develop clinical dengue (odds ratio [OR] = 3.21, 95% confidence interval [CI] = 1.29-7.97, P = 0.009), either DF (OR = 2.82, 95% CI = 1.00-7.97, P = 0.045) or DHF/DSS (OR = 3.90, 95% CI = 1.13-13.07, P = 0.024) than the asymptomatic dengue infection. Results of allelic distribution comparisons and logistic regression analysis also supported the same relationship. The results suggest complex nature of interacting factors in determining the course for severe dengue illness.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumandengue disease severityIAGP DNA:polymorphism:cds:p.H131R(human)RGD 
Fcgr2aRatdengue disease severityISOFCGR2A (Homo sapiens)DNA:polymorphism:cds:p.H131R(human)RGD 
Fcgr3Mousedengue disease severityISOFCGR2A (Homo sapiens)DNA:polymorphism:cds:p.H131R(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr2a  (Fc gamma receptor 2A)

Genes (Mus musculus)
Fcgr3  (Fc receptor, IgG, low affinity III)

Genes (Homo sapiens)
FCGR2A  (Fc gamma receptor IIa)

Additional Information