RGD Reference Report - Comprehensive transcriptome analysis identifies pathways with therapeutic potential in locally advanced cervical cancer. - Rat Genome Database

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Comprehensive transcriptome analysis identifies pathways with therapeutic potential in locally advanced cervical cancer.

Authors: Campos-Parra, Alma Delia  Padua-Bracho, Alejandra  Pedroza-Torres, Abraham  Figueroa-González, Gabriela  Fernández-Retana, Jorge  Millan-Catalan, Oliver  Peralta-Zaragoza, Oscar  Cantú de León, David  Herrera, Luis A  Pérez-Plasencia, Carlos 
Citation: Campos-Parra AD, etal., Gynecol Oncol. 2016 Nov;143(2):406-413. doi: 10.1016/j.ygyno.2016.08.327. Epub 2016 Aug 28.
RGD ID: 13441596
Pubmed: PMID:27581326   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ygyno.2016.08.327   (Journal Full-text)


OBJECTIVE: The objective of the present study was to provide genomic and transcriptomic information that may improve clinical outcomes for locally advanced cervical cancer (LACC) patients by searching for therapeutic targets or potential biomarkers through the analysis of significantly altered signaling pathways in LACC.
METHODS: Microarray-based transcriptome profiling of 89 tumor samples from women with LACC was performed. Through Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, significantly over-expressed genes in LACC were identified; these genes were validated by quantitative reverse transcription-polymerase chain reaction in an independent cohort, and the protein expression data were obtained from the Human Protein Atlas.
RESULTS: A transcriptome analysis revealed 7530 significantly over-expressed genes in LACC samples. By KEGG analysis, we found 93 dysregulated signaling pathways, including the JAK-STAT, NOTCH and mTOR-autophagy pathways, which were significantly upregulated. We confirmed the overexpression of the relevant genes of each pathway, such as NOTCH1, JAK2, STAM1, SOS1, ADAM17, PSEN1, NCSTN, RPS6, STK11/LKB1 and MLTS8/GBL in LACC compared with normal cervical tissue epithelia.
CONCLUSIONS: Through comprehensive genomic and transcriptomic analyses, this work provides information regarding signaling pathways with promising therapeutic targets, suggesting novel target therapies to be considered in future clinical trials for LACC patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cervical cancer  IEP 13441596mRNA:increased expression:cervix epithelium (human)RGD 
cervical cancer  ISOSOS1 (Homo sapiens)13441596; 13441596mRNA:increased expression:cervix epithelium (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sos1  (SOS Ras/Rac guanine nucleotide exchange factor 1)

Genes (Mus musculus)
Sos1  (SOS Ras/Rac guanine nucleotide exchange factor 1)

Genes (Homo sapiens)
SOS1  (SOS Ras/Rac guanine nucleotide exchange factor 1)


Additional Information