RGD Reference Report - Cadherin-9 regulates synapse-specific differentiation in the developing hippocampus. - Rat Genome Database

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Cadherin-9 regulates synapse-specific differentiation in the developing hippocampus.

Authors: Williams, Megan E  Wilke, Scott A  Daggett, Anthony  Davis, Elizabeth  Otto, Stefanie  Ravi, Deepak  Ripley, Beth  Bushong, Eric A  Ellisman, Mark H  Klein, Gerd  Ghosh, Anirvan 
Citation: Williams ME, etal., Neuron. 2011 Aug 25;71(4):640-55. doi: 10.1016/j.neuron.2011.06.019.
RGD ID: 13432233
Pubmed: PMID:21867881   (View Abstract at PubMed)
PMCID: PMC3272880   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neuron.2011.06.019   (Journal Full-text)

Our understanding of mechanisms that regulate the differentiation of specific classes of synapses is limited. Here, we investigate the formation of synapses between hippocampal dentate gyrus (DG) neurons and their target CA3 neurons and find that DG neurons preferentially form synapses with CA3 rather than DG or CA1 neurons in culture, suggesting that specific interactions between DG and CA3 neurons drive synapse formation. Cadherin-9 is expressed selectively in DG and CA3 neurons, and downregulation of cadherin-9 in CA3 neurons leads to a selective decrease in the number and size of DG synapses onto CA3 neurons. In addition, loss of cadherin-9 from DG or CA3 neurons in vivo leads to striking defects in the formation and differentiation of the DG-CA3 mossy fiber synapse. These observations indicate that cadherin-9 bidirectionally regulates DG-CA3 synapse development and highlight the critical role of differentially expressed molecular cues in establishing specific connections in the mammalian brain.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
synapse assembly involved_inIMP 13432233PMID:21867881SynGO-UCL 
synaptic membrane adhesion involved_inIMP 13432233PMID:21867881SynGO-UCL 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
postsynaptic membrane located_inIDA 13432233PMID:21867881SynGO-UCL 
presynaptic membrane located_inIDA 13432233PMID:21867881SynGO-UCL 

Objects Annotated

Genes (Rattus norvegicus)
Cdh9  (cadherin 9)


Additional Information