RGD Reference Report - Mapping of genetic determinants of the sympathoneural response to stress. - Rat Genome Database

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Mapping of genetic determinants of the sympathoneural response to stress.

Authors: Klimes, I  Weston, K  Gasperikova, D  Kovacs, P  Kvetnansky, R  Jezova, D  Dixon, R  Thompson, JR  Sebokova, E  Samani, NJ 
Citation: Klimes I, etal., Physiol Genomics 2005 Jan 20;20(2):183-7. Epub 2004 Nov 16.
RGD ID: 1332590
Pubmed: PMID:15547139   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00054.2004   (Journal Full-text)

Activation of the sympathoadrenal system (SAS, comprising the sympathetic nervous system and the adrenal medulla) in response to stressful stimuli is an important defense mechanism as well as a contributor to several cardiovascular diseases. There is variability in the SAS response to stress, although the extent to which this is genetically regulated is unclear. Some rodent models, including the hereditary hypertriglyceridemic (hHTg) rat, are hyperresponsive to stress. We investigated whether quantitative trait loci (QTLs) that affect sympathoadrenal response to stress could be identified. Second filial generation rats (n = 189) derived from a cross of the hHTg rat and the Brown Norway rat had plasma norepinephrine (NE) and epinephrine (Epi) levels, indices of activation of the sympathoneural and adrenal medulla components, respectively, measured in the resting state and in response to an immobilization stress. Responses were assessed early (20 min) and late (120 min) after the application of the stress. A genome scan was conducted using 153 microsatellite markers. Two QTLs (maximum peak LOD scores of 4.17 and 3.52, respectively) influencing both the early and late plasma NE response to stress were found on chromosome 10. Together, the QTLs accounted for approximately 20% of the total variation in both the early and late NE responses in the F(2) rats. Interestingly, the QTLs had no effect on plasma Epi response to stress. These findings provide evidence for a genetic determination of the response of a specific component of the SAS response to stress. Genetically determined variation in sympathetic nervous system response to stress may contribute to cardiovascular diseases.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Stresp6Ratincreased circulating noradrenaline level  IAGP  RGD 
Stresp7Ratincreased circulating noradrenaline level  IAGP  RGD 

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Objects Annotated

QTLs
Stresp6  (Stress response QTL 6)
Stresp7  (Stress response QTL 7)

Strains
BN/OrlIcoCrlf  (NA)
HTG  (Prague hypertriglyceridemic)


Additional Information