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Human LilrB2 is a ß-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.

Authors: Kim, Taeho  Vidal, George S  Djurisic, Maja  William, Christopher M  Birnbaum, Michael E  Garcia, K Christopher  Hyman, Bradley T  Shatz, Carla J 
Citation: Kim T, etal., Science. 2013 Sep 20;341(6152):1399-404. doi: 10.1126/science.1242077.
Pubmed: (View Article at PubMed) PMID:24052308
DOI: Full-text: DOI:10.1126/science.1242077

Soluble ß-amyloid (Aß) oligomers impair synaptic plasticity and cause synaptic loss associated with Alzheimer's disease (AD). We report that murine PirB (paired immunoglobulin-like receptor B) and its human ortholog LilrB2 (leukocyte immunoglobulin-like receptor B2), present in human brain, are receptors for Aß oligomers, with nanomolar affinity. The first two extracellular immunoglobulin (Ig) domains of PirB and LilrB2 mediate this interaction, leading to enhanced cofilin signaling, also seen in human AD brains. In mice, the deleterious effect of Aß oligomers on hippocampal long-term potentiation required PirB, and in a transgenic model of AD, PirB not only contributed to memory deficits present in adult mice, but also mediated loss of synaptic plasticity in juvenile visual cortex. These findings imply that LilrB2 contributes to human AD neuropathology and suggest therapeutic uses of blocking LilrB2 function.

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RGD Object Information
RGD ID: 13210542
Created: 2017-09-02
Species: All species
Last Modified: 2017-09-02
Status: ACTIVE



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