RGD Reference Report - [Association analysis of dopamine D4 receptor gene polymorphism and attention deficit hyperactivity disorder with/without disruptive behavior disorder].

General

[Association analysis of dopamine D4 receptor gene polymorphism and attention deficit hyperactivity disorder with/without disruptive behavior disorder].
Authors:	Guan, Li-li Wang, Yu-feng Li, Jun Wang, Bing Yang, Li Qian, Qiu-jin
Citation:	Guan LL, etal., Beijing Da Xue Xue Bao. 2007 Jun 18;39(3):233-6.
RGD ID:	13210522
Pubmed:	PMID:17572775 (View Abstract at PubMed)
OBJECTIVE: To examine the role of dopamine D4 receptor gene (DRD4) in attention deficit hyperactivity disorder (ADHD) with/without disruptive behavior disorder (DBD) by focusing on a-521C/T SNP within the promoter region of this gene. METHODS: A total of 401 DSM-IV ADHD children (including 284 trios) of Chinese Han descent were genotyped. Chi-square test and the transmission disequilibrium test (TDT) were used to test for associations in ADHD with and without DBD respectively. RESULTS: In the comparison of ADHD with (n=143) and without (n=258) DBD, the -521T allele ( chi(2) = 6.778, P= 0.009, OR= 1.485) and the TT genotype (chi(2) = 6.292,P=0.012,OR=1.729) showed higher frequency in children with ADHD and DBD simultaneously. For family based analysis, T allele of the -521C/T polymorphism was preferentially transmitted to ADHD children with comorbid DBD (n=100, chi(2) = 3.868,P=0.049), whereas no significant distortion was found in the transmission of the tested variant for ADHD without DBD (n=184, chi(2) = 0.223, P=0.637). CONCLUSION: Our findings suggest that the -521C/T SNP of DRD4 may contribute to the predisposition to ADHD with comorbid DBD. This study supports for the hypothesis that ADHD with comorbid DBD may be influenced by greater genetic effect compared to ADHD alone.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Attention Deficit and Disruptive Behavior Disorders		IAGP		13210522	associated with Attention Deficit Disorder with Hyperactivity and DNA:snp:promoter:g.-521C>T (human)	RGD
Attention Deficit and Disruptive Behavior Disorders		ISO	DRD4 (Homo sapiens)	13210522; 13210522	associated with Attention Deficit Disorder with Hyperactivity and DNA:snp:promoter:g.-521C>T (human)	RGD

Objects Annotated

Genes (Rattus norvegicus)

Drd4 (dopamine receptor D4)

Genes (Mus musculus)

Drd4 (dopamine receptor D4)

Genes (Homo sapiens)

DRD4 (dopamine receptor D4)

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[Association analysis of dopamine D4 receptor gene polymorphism and attention deficit hyperactivity disorder with/without disruptive behavior disorder].