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Variable number tandem repeats in dopamine receptor D4 in Tourette's syndrome.

Authors: Liu, Shiguo  Cui, Jiajia  Zhang, Xinhua  Wu, Weifeng  Niu, Haitao  Ma, Xu  Xu, Hongmei  Yi, Mingji 
Citation: Liu S, etal., Mov Disord. 2014 Nov;29(13):1687-91. doi: 10.1002/mds.26027. Epub 2014 Sep 25.
Pubmed: (View Article at PubMed) PMID:25258183
DOI: Full-text: DOI:10.1002/mds.26027

BACKGROUND: We attempted to clarify the association between dopamine receptor D4 (DRD4) 48-bp variable number of tandem repeats (VNTR) polymorphism and Tourette's syndrome.
METHODS: The DRD4 48-bp VNTR polymorphism was genotyped in 291 Tourette's syndrome patients (including 218 trios) and 405 controls. Chi-square and transmission disequilibrium test analysis were used to compare genetic distributions. We retrieved related studies in a meta-analysis to clarify the role of 2-repeat and 4-repeat alleles in the pathogenesis.
RESULTS: Obvious genotype and allele distribution differences were observed between patients and healthy controls for both 2-repeat and 4-repeat alleles. This was verified using transmission disequilibrium test analysis. Meta-analysis showed strong associations in both the total population and the Asian population.
CONCLUSIONS: The DRD4 48-bp VNTR polymorphism appears to be associated with Tourette's syndrome, with the 2-repeat allele performing a protective role and the 4-repeat allele a nonprotective role in the genesis of the disease.


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RGD Object Information
RGD ID: 13209010
Created: 2017-08-28
Species: All species
Last Modified: 2017-08-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.