RGD Reference Report - Bap29/31 influences the intracellular traffic of MHC class I molecules. - Rat Genome Database

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Bap29/31 influences the intracellular traffic of MHC class I molecules.

Authors: Paquet, ME  Cohen-Doyle, M  Shore, GC  Williams, DB 
Citation: Paquet ME, etal., J Immunol 2004 Jun 15;172(12):7548-55.
RGD ID: 1304474
Pubmed: PMID:15187134   (View Abstract at PubMed)

In this study, we examine the role of the putative cargo receptor B cell-associated protein (Bap)29/31 in the export of MHC class I molecules out of the endoplasmic reticulum (ER). We show that Bap31 binds to two allotypes of mouse class I molecules, with the interaction initiated at the time of H chain association with beta(2)-microglobulin and maintained until the class I molecule has left the ER. We also show that Bap31 is part of the peptide-loading complex, although is not required for its formation. Bap31 binds not only to class I molecules, but can bind to tapasin in the absence of class I. Consistent with an important role in recruiting class I molecules to transport vesicles, we show that in the absence of Bap29/31, there is a loss of class I colocalization with mSec31 (p137), a component of mammalian coat protein complex II coats. This observation is also associated with a delay in class I traffic from ER to Golgi. Our results are consistent with the view that class I molecules are largely recruited to ER exit sites by Bap29/31, and that Bap29/31 is a cargo receptor for MHC class I molecules.

Objects referenced in this article
Gene Bcap29 B cell receptor associated protein 29 Mus musculus
Gene Bcap31 B cell receptor associated protein 31 Mus musculus
Gene Bcap29 B-cell receptor-associated protein 29 Rattus norvegicus
Gene Bcap31 B-cell receptor-associated protein 31 Rattus norvegicus

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