RGD Reference Report - Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25. - Rat Genome Database

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Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25.

Authors: Lee, SK  Kim, YS  Lee, SS  Lee, YJ  Song, IS  Park, SC  Kozak, C  Yamada, Y 
Citation: Lee SK, etal., Genomics 2004 Feb;83(2):243-53.
RGD ID: 1304281
Pubmed: PMID:14706453   (View Abstract at PubMed)

A novel member of the Krox family of proteins, designated Krox-25, was identified by screening clones from the cDNA libraries of a rat incisor and mouse embryo craniofacial tissue. Rat and mouse Krox-25 mRNAs are about 2.4 kb long, encoding 225 and 224 amino acids, respectively. Krox-25 consists of five zinc finger motifs homologous to the Drosophila Kruppel segmentation gene and also contains several consensus amino acid sequences for a protein kinase C binding domain. Northern blot analysis revealed an intense expression of Krox-25 mRNA in rat and mouse teeth, although it was expressed weakly in other tissues, including calvaria, brain, lung, thymus, kidney, and submandibular gland of mouse. In situ hybridization showed that Krox-25 mRNA began to be expressed weakly in the early odontogenic mesenchyme and primitive enamel epithelium located at the apical end of the rat incisor, and Krox-25 expression increased in the presecretory ameloblasts and became intense in the secretory ameloblasts. This expression was also similar to the results of immunohistochemistry and Western blot, especially the Krox-25 localization in the nuclei of enamel epithelial cells. These results suggest that Krox-25 plays an important role as a transcription factor for the cytodifferentiation and amelogenesis of enamel epithelium.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
odontogenesis involved_inNAS 1304281PMID:14706453UniProt 
regulation of DNA-templated transcription involved_inNAS 1304281PMID:14706453UniProt 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nucleus located_inIDA 1304281PMID:14706453UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Zfp422  (zinc finger protein 422)

Objects referenced in this article
Gene Zfp422 zinc finger protein 422 Mus musculus

Additional Information