RGD Reference Report - Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat. - Rat Genome Database

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Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat.

Authors: Bilusic, M  Bataillard, A  Tschannen, MR  Gao, L  Barreto, NE  Vincent, M  Wang, T  Jacob, HJ  Sassard, J  Kwitek, AE 
Citation: Bilusic M, etal., Hypertension 2004 Nov;44(5):695-701. Epub 2004 Sep 27.
RGD ID: 1302893
Pubmed: PMID:15452030   (View Abstract at PubMed)
DOI: DOI:10.1161/01.HYP.0000144542.57306.5e   (Journal Full-text)

The complex nature of hypertension makes identifying the pathophysiology and its genetic contributions a challenging task. One powerful approach for the genetic dissection of blood pressure regulation is studying inbred rat models of hypertension, as they provide natural allele variants but reduced heterogeneity (both genetic and etiologic). Furthermore, the detailed physiologic studies to which the rat is amenable allow for the determination of intermediate phenotypes. We have performed a total genome scan in offspring of an F2 intercross between the Lyon hypertensive (LH) and Lyon normotensive rat strains to identify linkage of anthropometric, blood pressure, renal, metabolic, and endocrine phenotypes. Quantitative trait locus (QTL) regions involved in blood pressure regulation, end-stage organ damage, body and organ weight, and lipid metabolism in the LH rat were identified on chromosomes 1, 2, 3, 5, 7, 10, 13, and 17, with 2 phenotypes associated with the metabolic syndrome identified on chromosomes 1 and 17. Regions on chromosomes 2, 13, and 17 were revealed to be important for blood pressure regulation. Regions on chromosome 17 were found to significantly contribute to both metabolic homeostasis and blood pressure regulation; 2 aggregates of a total of 23 QTLs were identified, including several "intermediate phenotypes." These intermediate phenotypes may be used as closer surrogates to the mechanisms leading to hypertension and metabolic dysfunction in the LH rat.


Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abnormal body weight  QTM 1302893; 1302893; 1302893; 1302893; 1302893; 1302893 RGD 
abnormal circulating cholesterol level  QTM 1302893; 1302893 RGD 
abnormal circulating corticosterone level  QTM 1302893 RGD 
abnormal circulating creatinine level  QTM 1302893; 1302893; 1302893 RGD 
abnormal circulating HDL cholesterol level  QTM 1302893 RGD 
abnormal circulating insulin level  QTM 1302893 RGD 
abnormal circulating LDL cholesterol level  QTM 1302893 RGD 
abnormal circulating phospholipid level  QTM 1302893; 1302893 RGD 
abnormal circulating renin level  QTM 1302893; 1302893 RGD 
abnormal circulating VLDL cholesterol level  QTM 1302893; 1302893 RGD 
abnormal heart size  QTM 1302893; 1302893; 1302893; 1302893; 1302893 RGD 
abnormal kidney weight  QTM 1302893; 1302893; 1302893; 1302893; 1302893; 1302893; 1302893; 1302893; 1302893; 1302893 RGD 
abnormal systemic arterial blood pressure  QTM 1302893; 1302893; 1302893; 1302893; 1302893; 1302893; 1302893; 1302893 RGD 
abnormal tibia morphology  QTM 1302893; 1302893 RGD 
abnormal triglyceride level  QTM 1302893 RGD 
decreased circulating renin level  IAGP 1302893 RGD 
heart left ventricle hypertrophy  IAGP 1302893; 1302893; 1302893; 1302893; 1302893 RGD 
increased circulating cholesterol level  IAGP 1302893; 1302893 RGD 
increased circulating HDL cholesterol level  IAGP 1302893 RGD 
increased circulating triglyceride level  IAGP 1302893 RGD 
increased circulating VLDL cholesterol level  IAGP 1302893 RGD 
increased pulse pressure  IAGP 1302893; 1302893 RGD 
increased systemic arterial blood pressure  IAGP 1302893; 1302893 RGD 
increased systemic arterial diastolic blood pressure  IAGP 1302893; 1302893 RGD 
increased systemic arterial systolic blood pressure  IAGP 1302893; 1302893 RGD 
polyuria  QTM 1302893 RGD 
Objects Annotated

QTLs
Bp240  (Blood pressure QTL 240)
Bp241  (Blood pressure QTL 241)
Bp242  (Blood pressure QTL 242)
Bp243  (Blood pressure QTL 243)
Bp244  (Blood pressure QTL 244)
Bp245  (Blood pressure QTL 245)
Bp246  (Blood pressure QTL 246)
Bp247  (Blood pressure QTL 247)
Bw31  (Body weight QTL 31)
Bw32  (Body weight QTL 32)
Bw33  (Body weight QTL 33)
Bw34  (Body weight QTL 34)
Bw35  (Body weight QTL 35)
Bw36  (Body weight QTL 36)
Cm32  (Cardiac mass QTL 32)
Cm33  (Cardiac mass QTL 33)
Cm34  (Cardiac mass QTL 34)
Cm35  (Cardiac mass QTL35)
Cm36  (Cardiac mass QTL 36)
Insul1  (Insulin level QTL 1)
Kidm12  (Kidney mass QTL 12)
Kidm13  (Kidney mass QTL 13)
Kidm14  (Kidney mass QTL 14)
Kidm15  (Kidney mass QTL 15)
Kidm16  (Kidney mass QTL 16)
Kidm17  (Kidney mass QTL 17)
Kidm18  (Kidney mass QTL 18)
Kidm19  (Kidney mass QTL 19)
Kidm20  (Kidney mass QTL 20)
Kidm21  (Kidney mass QTL 21)
Lmblg1  (Limb length QTL 1)
Lmblg2  (Limb length QTL 2)
Rf46  (Renal function QTL 46)
Rf47  (Renal function QTL 47)
Rf48  (Renal function QTL 48)
Rf49  (Renal function QTL 49)
Rf50  (Renal function QTL 50)
Scl30  (Serum cholesterol level QTL 30)
Scl31  (Serum cholesterol level QTL 31)
Scl32  (Serum cholesterol level QTL 32)
Scl68  (Serum cholesterol level QTL 68)
Scort1  (Serum corticosterone level QTL 1)
Spl4  (Serum phospholipid level QTL 4)
Spl5  (Serum phospholipid level QTL 5)
Spl7  (Serum phospholipid level QTL 7)
Spl8  (Serum phospholipid level QTL 8)
Srn6  (Serum renin concentration QTL 6)
Stl13  (Serum triglyceride level QTL 13)

Strains
LH/Mav  (NA)
LN/Mav  (NA)

Objects referenced in this article
QTL Bp15 Blood pressure QTL 15 Rattus norvegicus
Strain LL/Mav null Rattus norvegicus

Additional Information