RGD Reference Report - Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.

Authors: Wallace, KJ  Wallis, RH  Collins, SC  Argoud, K  Kaisaki, PJ  Ktorza, A  Woon, PY  Bihoreau, MT  Gauguier, D 
Citation: Wallace KJ, etal., Physiol Genomics 2004 Sep 16;19(1):1-10. Epub 2004 Jul 20.
RGD ID: 1302801
Pubmed: (View Article at PubMed) PMID:15266047
DOI: Full-text: DOI:10.1152/physiolgenomics.00114.2004

Genetic studies in human populations and rodent models have identified regions of human chromosome 1q21-25 and rat chromosome 2 showing evidence of significant and replicated linkage to diabetes-related phenotypes. To investigate the relationship between the human and rat diabetes loci, we fine mapped the rat locus Nidd/gk2 linked to hyperinsulinemia in an F2 cross derived from the diabetic (type 2) Goto-Kakizaki (GK) rat and the Brown Norway (BN) control rat, and carried out its genetic and pathophysiological characterization in BN.GK congenic strains. Evidence of glucose intolerance and enhanced insulin secretion in a congenic strain allowed us to localize the underlying diabetes gene(s) in a rat chromosomal interval of approximately 3-6 cM conserved with an 11-Mb region of human 1q21-23. Positional diabetes candidate genes were tested for transcriptional changes between congenics and controls and sequence variations in a panel of inbred rat strains. Congenic strains of the GK rats represent powerful novel models for accurately defining the pathophysiological impact of diabetes gene(s) at the locus Nidd/gk2 and improving functional annotations of diabetes candidates in human 1q21-23.

Annotation

Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Phenotype Values via PhenoMiner

View PhenoMiner data from this reference here 

Objects Annotated

QTLs
Niddm62  (Non-insulin dependent diabetes mellitus QTL 62)

Objects referenced in this article
0 BN.GK-(D2Rat40-D2Got149)/Ox null All species
0 BN.GK-(D2Rat40-D2Wox35)/Ox null All species
0 BN.GK-(D2Wox30-D2Wox68)/Ox null All species
0 BN.GK-(D2Wox49-D2Rat70)/Ox null All species

Additional Information