RGD Reference Report - Dissecting quantitative trait loci into opposite blood pressure effects on Dahl rat chromosome 8 by congenic strains. - Rat Genome Database

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Dissecting quantitative trait loci into opposite blood pressure effects on Dahl rat chromosome 8 by congenic strains.

Authors: Ariyarajah, A  Palijan, A  Dutil, J  Prithiviraj, K  Deng, Y  Deng, AY 
Citation: Ariyarajah A, etal., J Hypertens 2004 Aug;22(8):1495-502.
RGD ID: 1302764
Pubmed: PMID:15257171   (View Abstract at PubMed)

OBJECTIVE: Our previous linkage analyses showed that there was likely a quantitative trait locus (QTL) for blood pressure (BP) on chromosome 8 (Chr 8) in the strain comparison between the Dahl salt-sensitive (S) and the Lewis (LEW) rats. The current work is to delineate the chromosome interval harboring this QTL by using congenic strains with different chromosome substitutions. METHODS: Two congenic strains were produced by replacing different segments of the S rats with the homologous segments of the LEW rats. A genome-wide marker screening was utilized to accelerate this process. The two strains generated are designated as C8S.L1 and C8S.L2, respectively. BPs of the rats were measured by telemetry. RESULTS: C8S.L1 showed a BP lower than that of S rats. In contrast, C8S.L2 did not have chromosome overlaps with C8S.L1, but unexpectedly, exhibited a BP-raising effect, higher than that of S rats. CONCLUSION: There are at least two QTLs present in a section of Chr 8 that possess opposite BP effects. The current congenic work reveals not only the presence of QTLs, but the complexity of QTLs on BP. The novel congenic strain with hypertension more severe than S provides a new model for studies in elucidating physiological mechanisms controlling BP.


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Objects referenced in this article
Marker D8Chm11 D8Chm11 Rattus norvegicus
Marker D8Chm3 D8Chm3 Rattus norvegicus
Marker D8Chm12 D8Chm12 Rattus norvegicus
Marker D8Chm6 D8Chm6 Rattus norvegicus
Marker D8Chm16 D8Chm16 Rattus norvegicus
Marker D8Chm2 D8Chm2 Rattus norvegicus
Marker D8Chm15 D8Chm15 Rattus norvegicus
Marker D8Chm14 D8Chm14 Rattus norvegicus
QTL Bp315 Blood pressure QTL 315 Rattus norvegicus
QTL Bp316 Blood pressure QTL 316 Rattus norvegicus
Strain SS.LEW-(D8Chm14-D8Rat16)/Ayd null Rattus norvegicus
Strain SS.LEW-(D8Rat56-D8Rat51)/Ayd null Rattus norvegicus

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