RGD Reference Report - RIP5 is a RIP-homologous inducer of cell death. - Rat Genome Database

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RIP5 is a RIP-homologous inducer of cell death.

Authors: Zha, J  Zhou, Q  Xu, LG  Chen, D  Li, L  Zhai, Z  Shu, HB 
Citation: Zha J, etal., Biochem Biophys Res Commun 2004 Jun 25;319(2):298-303.
RGD ID: 1302762
Pubmed: PMID:15178406   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2004.04.194   (Journal Full-text)

Members of the RIP serine/threonine kinase family are involved in activation of NF-kappaB, JNK, and p38, and induction of apoptosis. Here we report the identification of a novel RIP-homologous protein designated as RIP5. The C-terminus of RIP5 contains a kinase domain, which is mostly homologous with the kinase domain of RIP. RIP5 also contains a large unconserved N-terminal domain. Overexpression of RIP5 induces cell death with characteristic apoptotic morphology. Overexpression of RIP5 also induces DNA fragmentation and this is blocked by the caspase inhibitor crmA. However, RIP5-induced apoptotic morphology is not blocked by crmA. These findings suggest that RIP5 may induce both caspase-dependent apoptosis and caspase-independent cell death.

Objects referenced in this article
Gene Dstyk dual serine/threonine and tyrosine protein kinase Mus musculus
Gene Dstyk dual serine/threonine and tyrosine protein kinase Rattus norvegicus

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