RGD Reference Report - Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain. - Rat Genome Database

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Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain.

Authors: Zhou, Z  Ying, K  Dai, J  Tang, R  Wang, W  Huang, Y  Zhao, W  Xie, Y  Mao, Y 
Citation: Zhou Z, etal., Cytogenet Cell Genet 2001;92(3-4):231-6.
RGD ID: 1302302
Pubmed: PMID:11435694   (View Abstract at PubMed)
DOI: DOI:56909   (Journal Full-text)

During the large-scale sequencing analysis of a human fetal brain cDNA library, we isolated two cDNA clones encoding two novel proteins, which show 52% and 72% identity to the cyclophilin isoform 10 of C. elegans, respectively. Sequence analysis revealed these two cDNA clones are two different splicing variants of a novel cyclophilin-like gene (PPIL3). The PPIL3 gene was identified on a completely sequenced BAC (GenBank accession AC005037) from chromosome 2q33 between STS markers stSG2762 (proximal) and SHGC-3074 (distal), oriented toward the telomere. The PPIL3 gene consisted of eight exons spanning more than 18 kb of genomic DNA. RT-PCR analysis indicated that PPIL3 was ubiquitously expressed in adult human tissues.

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Gene PPIL3 peptidylprolyl isomerase like 3 Homo sapiens

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